主要高危人群抗结核治疗不良反应发生情况分析  

Adverse reactions of anti-tuberculosis drugs in major high-risk patients

作　　者：邓国防[1] 孙丽珍[1] 唐怡敏[1] 张培泽[1] 詹森林[1] 陈涛[1] 叶涛生[1] 

机构地区：[1]广东医学院附属深圳市第三人民医院肺二科,深圳518112

出　　处：《结核病与肺部健康杂志》2015年第4期215-218,共4页Journal of Tuberculosis and Lung Health

摘　　要：目的 分析主要高危人群结核病患者抗结核药物不良反应发生情况,为预防和处理其不良反应提供参考.方法 回顾性分析来自深圳市第三人民医院2011年1月至2014年12月住院和门诊随访的结核病患者,从病案室和门诊电子病历资料数据库查阅结核病患者有无出现不良反应并进行分类登记,纳入患者总数8492例.依据《2014年结核病诊疗年度回顾》分为普通人群结核病患者6689例（简称“普通人群组”）和主要高危人群结核病患者1803例（简称“高危人群组”）.其中主要高危人群组又分为合并糖尿病组732例、艾滋病组267例、慢性乙型肝炎组697例.记录各组患者抗结核治疗过程中出现的主要药物不良反应,使用SPSS 19.0软件进行统计学处理,采用x2检验比较各组主要不良反应发生率的差异,以P＜0.05为差异有统计学意义.结果 普通人群组总不良反应发生率13.9％（929/6689）,高危人群组总不良反应发生率26.4％ （476/1803）,两组比较,差异有统计学意义（x^2=33.785,P＜0.0001）;普通人群组患者的严重不良反应发生率1.1％（73/6689）,高危人群组患者的严重不良反应发生率6.4％ （116/1803）,两组比较,差异无统计学意义（x^2=6.012,P=0.198）;高危人群组中糖尿病患者的不良反应发生率24.7％ （181/732）,艾滋病患者的不良反应发生率36.3％ （97/267）,慢性乙型肝炎患者的不良反应发生率28.4％ （198/697）,三组比较,差异无统计学意义（x^2=17.30,P=0.068）.结论 主要高危人群结核病患者抗结核药物总不良反应发生率比普通人群高,需注意预防和处理其主要不良反应.[Abstract] Objective We analyzed the adverse drug reactions in patients with tuberculosis for providing re- ferences to prevent and deal with the adverse drug reactions in high-risk patients. Methods We retrospectively analyzed 8492 patients with tuberculosis of Third people＇s Hospital of Shenzhen from January 2011 to December 2014. All data were from the in-patient medical record room and the out-patient electronic medical record database. According to the annual review of tuberculosis treatment in 2014, 8492 patients were divided into general group （6689 cases） and high-risk group （1803 cases）. The high-risk group was divided into three subgroups with diabetes （732 cases）, AIDS （267 cases） and CHB （697 cases） differently. The major adverse reactions of anti-tuberculosis drugs in all groups were recorded. And the data were entered into the SPSS 19. 0 software suite and analyzed using Chi-square test. Results The overall adverse drug reaction rate was 13.9% （929/6689） in general patients and 26.4% （476/1803） in high-risk patients. The difference between the two groups was statistically significant （x^2 = 33. 785, P〈0. 0001）. The severe adverse drug reaction rate was 1.1% （73/6689） in general patients and 6.4%（116/1803） in high-risk patients. There was no statistically significant difference between the two groups （x^2= 6. 012,P=0. 198）. In high-risk subgroup, the adverse drug reaction rate was 24. 7% （181/732） in patients with diabetes mellitus; 36.3% （97/267） in patients with AIDS and 28. 4% （198/697） in patients with chronic hepatitis B. There was no statistically significant difference between the subgroups （x^2=17.30,P=0. 068）. Conclusion Ad- verse drug reactions are more common seen in high-risk patients than in general patients, we should pay more atten- tion to the prevention and treatment of high-risk patients.

关 键 词：结核病 抗结核药 药物毒性 

分 类 号：R969.3[医药卫生—药理学]