注射用骨瓜提取物治疗腰椎间盘突出症的疗效观察  

Gugua Extract Injection in the Treatment of Iumbar Disc Herniation.

作　　者：曹云岑 雷明星 刘耀升 王磊 周诗国[2] 刘蜀彬 

机构地区：[1]解放军307医院骨科,北京100071 [2]北京友谊医院统计室,北京100000

出　　处：《解放军药学学报》2015年第6期545-547,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的观察注射用骨瓜提取物治疗腰椎间盘突出症的临床疗效。方法采用前瞻性随机对照方法,纳入2010年5月至2014年5月期间保守治疗的120例腰椎间盘突出症患者。试验组60例,给予注射用骨瓜提取物治疗,对照组60例,给予骨肽注射液治疗。按Macnab评分标准比较2组患者治疗后6、12个月的总体临床疗效,运用视觉模拟评分(VAS)和腰椎日本骨科协会(JOA)功能评分评估2组患者治疗前、后1、3、6、12个月的疼痛和功能变化。结果 2组患者临床特征的基线数据差异无统计学意义(P>0.05);治疗后6和12个月的优良率分别为85%、75%(P<0.05)和72%、65%(P>0.05)。2组患者治疗后各时间点VAS评分均低于治疗前,JOA评分均高于治疗前,差异均有统计学意义(P<0.05)。治疗后1、3、6个月试验组VAS评分均低于对照组,JOA评分均高于对照组,差异有统计学意义(P<0.05),治疗后12个月2组评分均无统计学意义(P>0.05)。结论静脉滴注注射用骨瓜提取物与骨肽注射液均可明显改善腰椎间盘突出症患者的疼痛症状和功能。注射用骨瓜提取物的短期疗效优于骨肽注射液,两者的远期疗效相近。Objective To observe the clinical efficacy of Gugua extract injection on lumbar disc herniation.Methods One hundred and twenty patients with lumbar disc herniation who had received conservative treatment between May 2010 and May 2014 were included in this prospective and randomized study. Gugua extract injection was used in treatment group（ 60 patients）,while ossotide injection was used in control group（ 60 patients）. Macnab standard was used to evaluate the clinical effect at sixth and twelfth month in both groups. Visual analogue scales and Japanese orthopaedic association were used to evaluate the change of pain and functional outcome at the first,third,sixth and twelfth month in both groups. Results There was no significant difference in baseline data between the two groups（ P〈0. 05）.The excellent and good rate was 85% for treatment group and 75% for control group at the sixth month according to Macnab scoring standard（ P〈0. 05） and 72% for treatment group and 65% for control group at the twelfth month（ P〉0. 05）. The VAS scores in treatment group were below those in control group（ P〈0. 05） and the JOA scores in the treatment were significantly more than the scores in the control group（ P〈0. 05） at the first,third,and sixth month.However,there was no significant difference in the VAS scores or JOA scores in either group at the twelfth month（ P〉0. 05）. Conclusion The pain was alleviated and the function was improved in both groups of patients with lumbar disc herniation. The short-term efficacy of Gugua extract injection was better than that of ossotide injection a,but the long-term efficacy of Gugua extract injection was similar to that of ossotide injection.

关 键 词：注射用骨瓜提取物 椎间盘突出 临床疗效 

分 类 号：R95[医药卫生—药学]