新型可吸收镁合金支架在血管内应用及生物相容性  

Application and biocompatibility of a new absorbable magnesium alloy stent in blood vessels

作　　者：赵辉[1] 雷民[2] 

机构地区：[1]南阳市中心医院,河南省南阳市473000 [2]郑州大学第一附属医院,河南省郑州市450052

出　　处：《中国组织工程研究》2016年第8期1165-1170,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:动物体内实验发现,可吸收镁合金支架随着血管结构重塑的完成,可通过缓慢、有序、无毒害降解方式在体内完全降解。目的:探讨新型血管内可吸收镁合金支架在血管内的应用效果及生物相容性。方法:取42只防疫杂种犬,均于冠状动脉或者左侧股动脉置入可吸收镁合金支架,置入后1 d、3 d、5 d、1周、2周、3周、4周,进行冠状动脉或股动脉造影、炎性因子检测及靶血管内膜增生面积组织形态学分析。结果与结论:置入后1 d,支架形态完整,呈完全扩张状态;置入后3 d,支架出现部分降解现象;置入后1周,支架完全降解。置入后1-3周内,肿瘤坏死因子α、白细胞介素6、白细胞介素8水平不断下降。支架置入后2周,靶血管开始出现轻微的内膜增生,且随着时间的推移,增生面积逐渐增大,内膜增生面积百分比也逐渐增大。支架植入前后的血镁浓度无变化。结果表明,新型血管内可吸收镁合金支架置入血管1周可完全降解,并具有良好的生物相容性。BACKGROUND： In vivo animal experiments have found that magnesium alloy stents can be completely degraded in a slow, orderly and non-toxic manner following the vascular remodeling. OBJECTIVE： To investigate the applied effect and biocompatibility of a new type of magnesium alloy stent in blood vessels. METHODS： Forty-two crossbreed dogs were implanted with absorbable magnesium alloy stents via the coronary artery or left femoral artery. At days 1, 3, 5 and weeks 1, 2, 3, 4 after implantation, coronary or femoral artery angiography, inflammatory factor detection and morphological analysis targeting intimal hyperplasia were performed. RESULTS AND CONCLUSION： At 1 day after implantation, the stents had the complete shape and were fully extended; at 3 days after implantation, the stents were degraded partially; at 1 week after implantation, the stents were degraded completely. Within 1-3 weeks after implantation, the levels of tumor necrosis factor α, interleukin-6 and interleukin-8 continued to decrease. At 2 and 3 weeks after implantation, the target vessels presented with mild intimal hyperplasia. As time went on, the hyperplasia area increased gradually, and the percentage of intimal hyperplasia increased gradually. Blood magnesium concentration remained unchanged before and after stent implantation. The results show that the new absorbable magnesium alloy stent can be completely degraded within 1 week after stent implantation and has good biocompatibility.

关 键 词：组织支架 冠状血管 组织工程 生物材料 材料相容性 血管支架 镁合金支架 冠状动脉 生物降解性 生物相容性 病理学 内膜增生 

分 类 号：R318[医药卫生—生物医学工程]