SPME-GC/MS在线衍生测定尿液中多种有机锡化合物  

On-line derivatizationdetermination of ariety of organotin compounds in urineby SPME-GC/MS

作　　者：胡贵祥[1] 万益群[2] 朱惠芳[1] 

机构地区：[1]南昌市疾病预防控制中心,江西南昌330038 [2]南昌大学分析测试中心,江西南昌330047

出　　处：《南昌大学学报（理科版）》2015年第5期463-467,共5页Journal of Nanchang University(Natural Science)

基　　金：南昌市科技支撑计划项目(87号33)

摘　　要：采用固相微萃取(SPME)在线衍生进行前处理,建立GC/MS同时测定尿液中9种有机锡的方法。在优化的衍生条件40℃、400r·min^(-1)下考察了线性关系、回收率、精密度等参数。结果表明,该方法的线性相关系数为0.992 7~0.999 7,回收率在70%~120%之间,相对标准偏差低于12.2%。该方法操作简便、快速、无污染,初步运用于检测尿液中有机锡化合物,其中一丁基锡、三丁基锡、三丙基锡、三苯基锡均被检出,取得较满意的结果。The method of simultaneous determination of nine organotin compounds in urine by solid phase micro-extraction（SPME）-gas chromatography/mass spectrometry（GC/ MS）was explored in this study.Under the optimized conditions（40 ℃、400r·min^（-1））,the considerable linearties,recoveries andprecisionof the organotins were obtained.The results showedthe linearity correlation coefficients were between 0.9927 and 0.999 7.The average recoveries for organotins werebetween 70% and 120%,and the relative standard deviationsless than 12.2%.The method proposed in this paper waseasy,rapid andno interference for thedetermination of organotins in spirit.The established method was successfully applied to the determination oforganotin compounds in urine,and MBT,TBT,TPhT,TmeT were detected.

关 键 词：SPME-GCMS 有机锡 在线衍生 尿液 

分 类 号：O657.63[理学—分析化学]