胶原蛋白/壳聚糖/纳米SiO_2复合微球的制备与载药性能研究  

Preparation and drug loading property of collagen/chitosan/nano-silicon dioxide composite microsphere

作　　者：尚学峰[1] 李新年[1] 张玉苍[1,2] 符新[3] 王江[1,2] 

机构地区：[1]海南大学材料与化工学院,海口570228 [2]生物质废弃物资源化利用重点实验室,海口570228 [3]海南大学机电工程学院,海口570228

出　　处：《化工新型材料》2016年第3期245-248,共4页New Chemical Materials

基　　金：海南省重点科技计划项目(ZDXM 20120066);海南省自然科学基金(511106)

摘　　要：采用乳化交联法制备胶原蛋白/壳聚糖/纳米SiO_2复合微球。以司班80和液体石蜡为油相,混合溶液为水相,引入硬脂酸镁(MS)作助乳化剂,以SEM、FT-IR、UV、激光粒度仪为表征手段研究了油水体积比、搅拌速率、交联剂与混合溶液体积比和纳米SiO_2对复合微球的成球性及其载药释药性能的影响。结果表明,MS的助乳化效果较好,在纳米SiO_2和混合溶液质量比为2%(wt,质量分数)时,盐酸小檗碱载药微球的载药率为15.66%,包封率为66.52%,维生素D载药微球的载药率为3.08%,包封率为48.54%。结论:制备了粒度分布集中的药物缓释微球,纳米SiO_2使微球具有更好的缓释性能,且在pH较低时不易分解,减少粘附。Preparation of collagen/chitosan/nano-silicon composite microspheres by emulsion crosslinking method.With span80 and liquid paraffin as oil phase,introducing magnesium stearate as auxiliary emulsifier.Using SEM,FT-IR,UV,laser granularity instrument as characterization methods to study oil-water proportion,stirring speed,crosslinking agent/the combined solusion and nano-silicon dioxide＇s influences on microsphere forming and drug loading performance.The results showed that MS emulsification effect was good,and when nano-silicon dioxide concentration was 2%,berberine hydrochloride microsphere：drug-loading rate was 15.66% and encapsulation rate was 66.52%.Vitamin D microsphere：drug-loading rate was 3.08% and encapsulation rate was 48.54%.Conclusion：the sustained release microshperes＇ particle size distribution was concentrated,nano silicon dioxide made that microsphere had a better sustained release performance,made the microspheres harder to decompose in low pH,and reduced adhesion.

关 键 词：胶原蛋白 壳聚糖 纳米SIO2 微球 药物缓释 

分 类 号：TB33[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]