组织工程化软骨修复运动性软骨损伤  

Tissue-engineered cartilage for repair of sports-induced cartilage injury

作　　者：王大鹏[1] 张岚[2] 赵娜[1] 

机构地区：[1]沈阳药科大学社科与文体学院体育部,辽宁省沈阳市110016 [2]鞍山师范学院体育科学学院,辽宁省鞍山市114016

出　　处：《中国组织工程研究》2016年第7期1037-1043,共7页Chinese Journal of Tissue Engineering Research

基　　金：沈阳药科大学中青年教师事业发展支持计划资助课题;沈药大组人字【2014】9号文件~~

摘　　要：背景:各种原因引起的运动性软骨损伤非常常见,由于软骨自愈能力欠佳,其损伤后的修复一直以来都是一大难题。目的:综述组织软骨构建过程中不同类型种子细胞的特点,探讨体外组织工程软骨的构建在修复运动性软骨损伤中的应用。方法:检索PubM ed,万方及CNKI数据库与组织工程化软骨修复运动性软骨损伤,以及组织工程化软构建中干细胞和支材料应用相关的文章。共检索到文献190篇,排除重复性研究,最终纳入47篇进行综述。结果与结论:骨髓间充质干细胞在不同诱导条件下可以向软骨细胞分化,与脂肪间充质干细胞和脐带间充质干细胞相比,具有更好的软骨细胞分化潜能,但其安全性还待进一步研究。良好的支架材料不仅可以诱导干细胞的分化,也是软骨构建的成功与否的关键,复合材料是今后支架材料研究的发展方向。BACKGROUND： Sports-induced cartilage injury is very common; due to the poor self-healing capacity of the cartilage, cartilage repair has always been a difficult problem. OBJECTIVE： To review the features of different seed cells in tissue-engineered cartilage construction and to explore the application of tissue-engineered cartilage construction in the repair of sports-induced cartilage injury in vitro. METHODS： We searched PubM ed database, Wanfang database and CNKI database for articles related to tissue-engineered cartilage repair of sports-induced cartilage injuries, as well as stem cells and scaffold materials used in tissue-engineered cartilage construction. Totally 190 articles were retrieved, and finally 47 articles were included in result analysis after repetitive studies were excluded. RESULTS AND CONCLUSION： Bone marrow mesenchymal stem cells under different conditions can differentiate into chondrocytes, and have better potential of chondrogenic differentiation compared with adipose-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells. But, their safety still needs to be further studied. Good scaffolds cannot only induce stem cell differentiation, but also be the key to cartilage construction. Composite materials are the future direction of the scaffold research.

关 键 词：软骨 软骨细胞 运动医学 创伤和损伤 组织工程 组织构建 软骨组织工程 运动性软骨损伤 组织工程软骨 软骨缺损 支架材料 

分 类 号：R318[医药卫生—生物医学工程]