对二氧环己酮与N^ε-苄氧羰基-L-赖氨酸无规共聚物的合成及其共聚反应机理  

Poly（p-dioxanone-co-N^ε -carbobenzoxy-L-lysine ） Synthesis and Mechanism of Copolymerization

作　　者：王冰[1] 董军[1] 陈栋梁[2] 熊成东[2] 

机构地区：[1]川北医学院基础医学院化学教研室,四川南充637000 [2]中国科学院成都有机化学研究所,四川成都610041

出　　处：《合成化学》2016年第4期333-337,共5页Chinese Journal of Synthetic Chemistry

基　　金：四川省教育厅重点项目(自然科学)(15ZA0207)

摘　　要：通过对二氧环己酮与Nε-苄氧羰基-L-赖氨酸-N-羧酸酐本体共聚的方法制备了聚对二氧环己酮-Nε-苄氧羰基-L-赖氨酸的无规共聚物(PPCLAs),其结构1H NMR和GPC表征。考察了聚合反应时间及催化剂用量对PPCLAs平均分子量的影响,并提出了"先竞争引发,再大分子间缩聚"的共聚反应机理。The copolymers （ PPCLAs）, poly （p-dioxanone-co-N^ε-carbobenzoxy-L-lysine ）, were synthesized by bulk eopolymerization of p-dioxanone ,sith N^ε-earbobenzoxy-L-lysine-N-carboxyanhydride. The structures were characterized by ^1H NMR and GPC. The effects of catalyst quantities and reaction time on the average molecular weights of PPCLAs were investigated. The copolymerization mechanism was deduced as ＂competitive initiate-condensation polymerization between macromolecules＂.

关 键 词：聚对二氧环己酮 Nε-苄氧羰基-L-赖氨酸 无规共聚物 合成 共聚机理 

分 类 号：O63[理学—高分子化学]