血清IL-32与急性心梗患者预后的相关性分析  

Serum levels of interleukin-32 and cardiovascular outcomes in patients with acute myocardial infarction

作　　者：陈家林[1] 

机构地区：[1]深圳市第二人民医院心血管内科,广东深圳518034

出　　处：《安徽医药》2016年第3期512-515,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的 探讨急性心肌梗死（AMI）患者血清白细胞介素-32（IL-32）与预后心血管事件风险的关系。方法 研究对象为190例深圳市第二人民医院心内科住院的ST段抬高或非ST段抬高AMI患者。分析血清IL-32与心梗患者2年内复发或死亡风险的相关性。结果 IL-32对已知的心血管危险因素具有显著的影响,如C-反应蛋白（CRP）以及他汀类药物（HR=1.40（1.03-1.91）;P=0.03）。IL-32血管内皮细胞黏附分子（VCAM-1）的表达。AMI患者低（低于中位数）IL-32水平和高（高于中位数）VCAM-1水平增加心血管事件发生的风险（HR=2.22（1.32-3.75）;P=0.002）。结论 血清低水平IL-32和AMI患者心血管事发生相关。Objective To investigate the relationship between serum levels of interleukin -32 （IL -32）and the risk of cardiovascular events in patients with acute myocardial infarction（AMI）.Methods We used data from 190 patients enrolled in the prospective,acute ST elevation,or non -ST elevation MI of our department in Shenzhen Second People’s Hospital.Serum levels of IL -32 were associat-ed with the risk of all -cause death and recurrent myocardial infarction（MI）at 2 years,with levels of IL -32 below the median indica-tive of aworse outcome.Results The impact of IL -32 remained significant after adjustment for known cardiovascular risk factors,C-reactive protein,and treatments including statins：hazard ratio （HR）=1.40 （1.03 -1.91）;P =0.03.IL -32 reduced endothelial vascular cell adhesion molecule （VCAM-1）expression.Patients with low （below the median）IL -32 levels and high （above the median）VCAM-1 levels were at particularly increased risk of death and MI：HR =2.22 （1.32 -3.75）compared with the high IL-17 /low sVCAM-1 group （P =0.002）.Conclusion Low serum levels of IL -32 are associated with a higher risk of major cardio-vascular events in patients with AMI.

关 键 词：急性心肌梗死 白细胞介素-32 炎症 

分 类 号：R542.22[医药卫生—心血管疾病]