729例临床药品不良反应报告分析  

Analysis on 729 Cases of Clinical Adverse Drug Reactions

作　　者：于海燕[1] 何粤红[1] 胥小叶[1] 

机构地区：[1]云南省精神病医院药学部,云南昆明650224

出　　处：《中国药物评价》2016年第1期44-46,共3页Chinese Journal of Drug Evaluation

摘　　要：目的：分析临床药品不良反应（ADR）的情况,为临床合理用药提供指导。方法：对我院2010-2015年收集上报至国家药品不良反应监测系统的729例有效报告进行统计、分析、评价。结果：729例ADR报告中,患者年龄≤18岁45例、19-30岁207例、31-45岁237例、46-60岁168例、61-80岁65例、〉80岁7例;给药途径为口服701例、肌内注射19例、静脉滴注6例、静脉注射2例、皮下注射1例;共涉及药物29种,41个品规,累及的器官或系统7个,神经系统损害520例、消化系统损害103例、心血管系统损害61例、内分泌系统损害18例、免疫系统12例、血液系统11例、泌尿系统4例。不良反应的转归好转571例（78.33%）,痊愈158（21.67%）。结论：我院31-45岁患者ADR发生率最高（32.51%）,出现ADR的主要给药途径是口服给药,出现ADR最多的药物是利培酮,ADR以神经系统损害为主。应加强ADR的监测和报告,以促进临床合理用药、确保患者用药安全。Objective： To analyze the clinical adverse drug reactions（ ADR）,and provide guidances for clinical rational drug use. Methods： 729 cases of ADR collected which were monitored by the national ADR system in our hospital during the year between2010 and 2015. And then the effective statistics,analysis and evaluation works were done with data. Results： In the 729 patients,there was 45 cases whose age were less than 18 years old,207 cases were the age of 19 to 30 years old,237 cases were the age of 31 to 45,168 cases were the age of 46 to 60,65 cases were the age of 61 to 80,and 7 cases were the age more than 80 years old; Meditation methods for 701 cases were oral medicine,19 cases were intramuscular injection,6 cases were intravenous injection,2 cases were venous injection,1 case subcutaneous injection. 29 kinds of medicines were involved,among which there were 41 gauges. And there were 7 organs or systems involved,among which the nervous system damage was 520 cases,digestive system damage was 103 cases,cardiovascular system damage was 61 cases,endocrine system damage was 18 cases,immune system damage was 12 cases,blood system damage was 11 cases,urinary system damage was 4 cases. The improved outcome of adverse reactions was 571 cases（ 78. 33%）,the recovery outcome was 158 cases（ 21. 67%）. Conclusion： The incidence of ADR in our hospital was the highest during the age of 31 to 45（ 32. 51%）,the method of adverse reaction was mainly the oral medicine,the adverse reactions were given priority with the nervous system damage. And the risperdal was reported the most ADR. ADR monitoring and reporting should be strengthened to promote the rational use of drugs of the clinical.

关 键 词：药品不良反应 药品不良反应监测 合理用药 住院患者 

分 类 号：R95[医药卫生—药学]