6,19-环氧甾类化合物合成研究进展  

The Synthesis Development of 6,19-Oxido-bridged Steroids

作　　者：盛芳玲 金灿[1] 

机构地区：[1]浙江工业大学药学院,杭州杭州310014

出　　处：《浙江化工》2016年第3期4-8,共5页Zhejiang Chemical Industry

摘　　要：6,19-环氧甾体化合物主要用来制备孕甾类化合物和19-去甲基类固醇化合物,其主要通过6β-羟基甾体在光照并有氧化剂参与下形成烷氧自由基中间体来合成的。综述了甾体6,19位氧桥的几种代表性的合成方法,并对合成方法进行了分析总结。6,19-oxido-bridged steroids are the key intermediates for the preparation of 19-functionalized and 19-nor steroids compounds. 6,19-oxido-bridged steroids are prepared by the formation of alkoxyl radicals which are generated through irradiation of 6β-hydroxy steroids accompanying with oxidants. This article summarized some representative synthetic methods of the 6,19-oxido-bridged steroids and reviewed the advantages and disadvantages of these methods.

关 键 词：6 19-环氧甾体化合物 6β-羟基甾体 光照环合反应 

分 类 号：O621.3[理学—有机化学]