冠状动脉多支狭窄患者介入治疗后对比剂肾病发生率及危险因素  

Morbidity and related factors of contrast-induced nephropathy in patients with multivessle disease undergoing percutaneous coronary intervention

作　　者：胡大军[1] 杜巍[1] 钟敏[1] 周亚南[1] 唐翠英[1] 

机构地区：[1]郴州市第一人民医院心血管内科,湖南郴州423000

出　　处：《湘南学院学报（医学版）》2016年第1期1-3,共3页Journal of Xiangnan University（Medical Sciences）

基　　金：郴州市科技局科研项目(CZ2013083);郴州市第一人民医院院级课题

摘　　要：目的探讨冠状动脉多支狭窄病变(MVD)患者行经皮冠状动脉介入(PCI)治疗后对比剂肾病(CIN)发生率及其危险因素。方法入选湖南省郴州市第一人民医院120例行PCI治疗的MVD患者,通过分析血肌酐指标得出CIN的发生率;比较CIN组及非CIN组相关因素,采用Logistic回归分析校正各危险因素与CIN风险的相关性。结果120例MVD患者中发生34例CIN,其CIN发生率为28.33%。多因素Logistic回归分析发现年龄、心衰、内生肌酐清除率及2型糖尿病与CIN发生率显著相关(P<0.05)。结论 MVD患者行PCI术CIN的发生率较高,年龄、心衰、2型糖尿病及内生肌酐清除率为CIN发生的危险因素。Objective To investigate the morbidity and risk factors of contrast- induced nephropathy（ CIN） in patients with multivessle disease undergoing percutaneous coronary intervention（ PCI）. Methods One hundred and twenty consecutive patients who underwent PCI were enrolled. The morbidity was counted by measuring serum creatinine before and 72 h after PCI. The patients were divided into CIN group and non- CIN group. Baseline characteristics were compared between the two groups. Logistic regression was used to investigate the risk factors of CIN. Results The morbidity of CIN was 28. 33%. Multiple logistic regression analyses showed that CIN was associated with old age,heart failure,pre- contrast creatinine clearance,and type 2 diabetes（ P〈0. 05）. Conlusion The morbidity of CIN in patients with MVD is higher than the average incidence reported in the literature. Old age,heart failure,pre- contrast creatinine clearance,and type2 diabetes are independent risk factors for CIN.

关 键 词：冠状动脉多支病变 对比剂肾病 经皮冠状动脉介入 

分 类 号：R541.4[医药卫生—心血管疾病]