抗环瓜氨酸肽、纤维蛋白原和D-二聚体与类风湿关节炎患者病情活动性的关系研究  

The Relationship of CCP,Fg and D-dimer with Disease Activity of Rheumatoid Arthritis

作　　者：李艳丽[1] 喻雄杰[1] 廖勇敢[1] 李晓雯[1] 郑海燕[1] 黄明炜[1] 郑黎[1] 廖春分[1] 

机构地区：[1]湖北医药学院附属十堰市人民医院内分泌科,湖北十堰442000

出　　处：《医学综述》2016年第7期1388-1390,共3页Medical Recapitulate

摘　　要：目的探讨抗环瓜氨酸肽（CCP）、纤维蛋白原（Fg）和D-二聚体与类风湿关节炎（RA）患者病情活动性的关系。方法选取2014年1~12月湖北医药学院附属十堰市人民医院60例RA患者为研究对象（RA组）,同时选取60例正常体检者为对照组,采用酶联免疫吸附试验法测定CCP、Fg及D-二聚体水平。结果 RA组患者CCP、Fg及D-二聚体水平高于对照组,差异有统计学意义[（59±22）U/L比（15±4）U/L,（3.80±0.18）g/L比（2.78±0.29）g/L,（963±112）μg/L比（321±23）μg/L,P〈0.01]。RA组低活动度及高活动度患者CCP、Fg及D-二聚体水平显著高于RA缓解期[（60±5）U/L、（83±5）U/L比（35±5）U/L,（3.56±0.29）g/L、（4.78±0.36）g/L比（2.98±0.42）g/L,（789±92）μg/L、（1245±110）μg/L比（499±85）μg/L],差异有统计学意义（P〈0.01）。RA患者血浆CCP、Fg、D-二聚体与病情活动度指数（DAS）呈正相关（r=0.396,0.412,0.426,P〈0.05）。结论 RA患者血清CCP、Fg及D-二聚体水平显著高于正常人群,且与疾病活动度有密切的关系,提示纤溶系统激活可能在RA疾病发生及进展中起到重要的作用。Objective To discuss relationship of cyclic citrullinated peptide（ CCP）,fibrinogen（ Fg）and D-dimer（ D-D） with disease activity of rheumatoid arthritis（ RA）. Methods Total of 60 RA patients from Hubei Medical College Afliliated Shiyan People’ s Hospital during January and December 2014 were included as objects（ RA group）,while another 60 people during the same period for health examination were included as control group. The levels of CCP,Fg and D-D of the two groups were measured with enzymelinked immunosorbent assay（ ELISA）. Results The levels of CCP,Fg,D-D of the RA group were higher than the control group[（ 59 ± 22） U / L vs（ 15 ± 4） U / L,（ 3. 80 ± 0. 18） g / L vs（ 2. 78 ± 0. 29） g / L,（ 963 ± 112） μg/L vs（ 321 ± 23） μg/L,P 〈 0. 01]. CCP,Fg and DD levels of low activity and high activity period patients of RA group were significantly higher than the relief period patients of RA group [（ 60 ±5） U / L,（ 83 ± 5） U / L vs（ 35 ± 5） U / L,（ 3. 56 ± 0. 29） g / L,（ 4. 78 ± 0. 36） g / L vs（ 2. 98 ± 0. 42） g / L,（ 789 ±92） μg/L,（ 1245 ± 110） μg/L vs（ 499 ± 85） μg/L],the difference was statistically significant（ P 〈 0. 01）. The CCP,Fg,D-D of RA group were positively correlated with disease activity index（ DAS）（ r = 0. 396,0. 412,0. 426,P 〈 0. 05）. Conclusion Serum CCP,Fg and D-D levels of RA patients are significantly higher than the normal population,which are closely related to disease activity,suggesting that activation of the fibrinolytic system may play an important role in the occurrence and progress of RA.

关 键 词：类风湿关节炎 抗环瓜氨酸肽 纤维蛋白原 D-二聚体 

分 类 号：R446.62[医药卫生—诊断学]