血清叶酸和红细胞叶酸检测的临床应用  

Clinical application of serum folate and red blood cell folate determinations

作　　者：陈朴[1] 潘柏申[1] 

机构地区：[1]复旦大学附属中山医院检验科,上海200032

出　　处：《检验医学》2016年第3期232-236,共5页Laboratory Medicine

基　　金：国家临床重点检验专科建设项目资助

摘　　要：叶酸缺乏与新生儿神经管缺陷症及巨幼细胞性贫血密切相关。血清叶酸和红细胞叶酸检测是临床诊断叶酸缺乏的主要依据,但二者的检测方法目前均尚未标准化。文章对叶酸的生物特性、叶酸缺乏的病因、流行病学研究、临床表现、诊断临界值和实验室检测进行了介绍。Folate deficiency is closely related to neural tube defect in newborns and megaloblastic anemia. The determinations of serum folate and red blood cell folate could be primary evidence for folate deficiency. However,the determination methods have not yet been standardized. This article will describe the biological characteristics of folate,the causes of folate deficiency,its epidemiological study,clinical manifestation,diagnostic cut-off values and the clinical application of folate determinations.

关 键 词：叶酸 巨幼红细胞性贫血 神经管缺陷 

分 类 号：R446.1[医药卫生—诊断学]