AS合并高尿酸血症患者血清sCD163水平的研究  

Study of serum sC D163 level in ankylosing spondylitis patients complicated with hyperuricemia

作　　者：钟毅[1] 陈泽娜 张萍萍[1] 李秋霞[1] 曹双燕[1] 魏秋静[1] 祁军[1] 古洁若[1] 

机构地区：[1]中山大学附属第三医院风湿免疫科,广州510630

出　　处：《新医学》2016年第3期150-152,共3页Journal of New Medicine

摘　　要：目的探讨sCD163及高尿酸在强直性脊柱炎(AS)中的作用。方法检测26例合并高尿酸血症AS患者(AS高尿酸组)、20例尿酸正常AS患者(AS尿酸正常组)以及20名健康志愿者(健康对照组)血清中的尿酸水平及sCD163水平(ELISA法)。AS疾病活动程度通过血清CRP、ESR、ASDAS-CRP评分、ASDAS-ESR评分、疾病活动指数(BASDAI)进行评估。比较3组的各项结果。采用Pearson相关分析各项指标与sCD163的相关性。结果 AS高尿酸组、AS尿酸正常组及健康对照组间sCD163水平比较差异有统计学意义[(621.8±296.5)pg/ml vs.(791.2±343.3)pg/ml vs.(912.9±492.2)pg/ml,P=0.032],其中AS高尿酸组sCD163水平低于AS尿酸正常组(P=0.026)。AS高尿酸组炎症指标、ASDAS-CRP评分、ASDAS-ESR评分及BASDAI均低于AS尿酸正常组(P均<0.05)。Pearson相关分析结果显示,在2个AS病例组中,sCD163水平与血清尿酸(r=-0.292,P=0.049)、ESR(r=0.299,P=0.044)及ASDAS-ESR评分(r=0.292,P=0.049)具有相关性。结论 sCD163能在一定程度上反映AS炎症状态,AS合并高尿酸血症与较低的炎症反应及疾病活动度密切相关。Objective To investigate the roles of sCD163 level and hyperuricemia in ankylosing spondylitis （AS）. Methods Twenty six AS patients with hyperuricemia, 20 AS patients with normal serum u- ric acid （SUA） and 20 healthy volunteers were enrolled. Serum uric acid and sCD163 levels were detected by ELISA. The disease activity of AS was evaluated by CRP, ESR, ASDAS-CRP score, ASDAS-ESR score and Bath Ankylosing spondylitis disease activity index （BASDAI）. Each parameter was statistically compared a- mong three groups. The correlation between each parameter and sCD163 level was analyzed by Pearson correla- tion analysis. Results Serum sCD163 level significantly differed among three groups [ （621.8 _＋296. 5） pg/ ml vs. （791.2 _＋343.3） pg/ml vs. （912. 9 _＋492. 2） pg/ml, P = 0. 032]. Serum sCD163 level in the AS with hyperurieemia group was significantly lower than that in the AS with normal uric acid group （ P = 0. 026 ）. Compared with AS patients with normal uric acid, inflammatory parameters, ASDAS-CRP score, ASDAS-ESR score and BASDAI were equally significantly lower in AS counterparts complicated with hyperuricemia （ all P 〈 0. 05 ）. Pearson correlation analysis revealed that sCD163 level was correlated with serum uric acid level （ r = - 0.292, P = 0.049） , ESR （ r = 0. 299, P = 0. 044） and ASDAS-ESR score （ r = 0. 292, P = 0. 049 ） in AS patients. Conclusions sCD163 level could reflect the inflammatory status of AS patients to certain extent. High level of uric acid in AS patients closely correlates with low inflammatory responses and disease activity.

关 键 词：高尿酸血症 强直性脊柱炎 sCD163 

分 类 号：R593.23[医药卫生—内科学] R589.7[医药卫生—临床医学]