广东佛山市三水区部分高尿酸血症患者的调查研究  

Investigation of part of the patients with hyperuricemia in Sanshui District of Foshan

作　　者：余俊文[1] 王林键 陈泽娜 陈发胜[1] 杨思为[1] 胡陈[1] 刘锡坚[1] 

机构地区：[1]佛山市中医院三水医院,佛山528100 [2]中山大学附属第三医院风湿免疫科,广州510630

出　　处：《新医学》2016年第3期170-174,共5页Journal of New Medicine

摘　　要：目的分析广东佛山市三水区部分高尿酸血症（HUA）患者的血尿酸水平及其合并高血压病、肾功能不全的情况。方法收集行常规体检发现HUA的14289例患者的血尿酸、血清肌酐、血压的检测结果，计算每位患者的估计肾小球滤过率。比较不同性别、年龄HUA患者的血尿酸水平，比较不同性别、血尿酸水平HUA患者合并高血压病及肾功能不全的情况。结果14289例HUA患者男女比例为11．3：1；男性患者年龄为（40．4±13．9）岁，小于女性患者（47．5±17．4）岁（P〈0．001）。男性患者血尿酸水平为（479．5±54．4）μmol／L，高于女性患者（464．0±45．8）μmol／L，两者比较差异有统计学意义（P〈0．001）。21—60岁的4个年龄组男性血尿酸水平均高于女性（P均〈0．001），而60岁以上及20岁以下年龄组男、女患者的血尿酸水平比较差异无统计学意义（尸均〉0．05）。男性各年龄组之间血尿酸水平无明显差异（P〉0．05）；但女性各年龄组之间血尿酸水平有差异（P：0．001），进一步两两比较发现，71—80岁年龄组与21～30和31—40岁2个年龄组的血尿酸水平比较差异有统计学意义（P均〈0．001）。男性HUA患者合并高血压病及肾功能不全的百分率均小于女性HUA患者（P均〈0．001）。血尿酸水平〉480μmol／L组合并高血压病及肾功能不全的百分率均高于≤480μmol／L组（P均〈0．001）。结论广东佛山市三水区部分体检者中HUA患者以男性为主，女性发病年龄较男性晚；男性患者血尿酸水平较女性患者高；老年女性患者的血尿酸水平较年轻患者高；女性及血尿酸水平较高者的高血压病、肾功能不全的患病率较高。Objective To investigate the blood uric acid levels and related complications, such as hypertension and renal insufficiency of part of the patients with hyperuricemia （HUA） from Sanshui District of Foshan in Guangdong Province. Methods Clinical data including blood uric acid, serum creatinine and blood pressure of 14 289 patients diagnosed with HUA after routine physical examination were collected. The esti- mated glomeruiar filtration rate of each patient was calculated. The blood uric acid levels and the incidence of hypertension and renal insufficiency complications were statistically compared according to different genders and ages. Results Among 14 289 HUA patients, 13 124 （91.8%） were male and 1 165 （8.2%） female with a male-to-female ratio of 11.3 ： 1. The male patients were aged （ 40. 4 ± 13.9 ） years on average, significantly younger compared with （47.5 ± 17.4） years of female counterparts （ P 〈0. 001 ） . The mean blood uric acid level was （479. 5 ± 54.4） μmol/L for male patients, significantly higher compared with （464. 0 ± 45.8 ） ixmol/L for female counterparts （ P 〈 0. 001 ）. The male patients aged between 21 and 60 years had significant- ly higher levels of blood uric acid than female counterparts （ all P 〈0. 001 ）, whereas the levels did not signifi- cantly differ between male and female patients aged 〉 60 years or 〈 20 years （ both P 〉 0.05）. The levels of blood uric acid did not significantly differ among male patients of different ages （P 〉 0. 05）, whereas statistical significance was noted among female counterparts of different ages （ P = 0. 001 ） and between female individuals aged 71-80 years and those aged 21-30 and 31-40 years （both P 〈0. 001 ）. The percentage of male HUA pa- tients complicated with hypertension and renal insufficiency was significantly lower compared with that of female HUA counterparts （ both P 〈0. 001 ）. The percentage of patients with blood uric acid levels 〉 480μmol/L was considerabl

关 键 词：高尿酸血症 血尿酸 高血压病 慢性肾功能不全 

分 类 号：R589.7[医药卫生—内分泌]