梅州地区居民高尿酸血症及痛风的流行病学调查  

Epidemiologic study of hyperuricemia and gout in Meizhou Area

作　　者：方霖楷[1] 陈启云[2] 温义权[2] 古洁若[1] 

机构地区：[1]中山大学附属第三医院风湿免疫科,广州510630 [2]中山大学附属第三医院粤东医院风湿免疫科,梅州514011

出　　处：《新医学》2016年第3期183-186,共4页Journal of New Medicine

摘　　要：目的了解梅州地区居民痛风及高尿酸血症(HUA)的流行病学特点。方法以中山大学附属第三医院粤东医院健康体检人群为研究对象,分别进行问卷调查、体格检查和实验室检查,重点采集受访者的痛风及HUA等慢性疾病患病情况、饮食习惯及结构、代谢综合征相关体征(血清尿酸、血脂、血糖、肝肾功能)等。结果 6 743名体检人群中,男性HUA标化患病率为16.4%,女性为8.1%。男性痛风标化患病率1.8%,女性为0.4%。HUA患者痛风的患病率为9.2%。HUA及痛风患者中,男性血清尿酸水平均明显高于女性(P均<0.01)。HUA患者合并2型糖尿病、脂代谢紊乱、高血压病、肥胖的几率分别为26.2%、58.3%、60.6%、12.1%,痛风患者相应为27.5%、59.7%、55.6%、10.7%。习惯性进食腌面、偏好动物性油脂、高血压病、血尿素氮过高,为该地区HUA或痛风发病的独立危险因素。结论梅州地区HUA及痛风患病率较高,因地制宜、有针对性地改良民俗、生活、饮食习惯中的不良因素,可有助于防治HUA及痛风。Objective To determine the epidemiologic characteristics of hyperuricemia （HUA） and gout among the residents in Meizhou area. Methods 6 743 individuals receiving physical examination in the Third Affiliated Hospital of Sun Yat-sen University-Yuedong Hospital were enrolled in this study. All partici- pants received questionnaire survey, physical and laboratory examination. The prevalence of gout, HUA and chronic diseases, dietary habit and composition and physical signs of metabolism syndrome （ serum uric acid, blood lipid, blood glucose, liver and renal function） were collected. Results Among 6 743 cases, the stand- ardized prevalence of HUA in the male subjects was 16.4% and 8. 1% for female counterparts. The standard- ized prevalence of gout in the male individuals was 1.8% and 0. 4% for the female. The prevalence of gout in HUA patients was 9. 2%. Serum uric acid in male patients with gout and HUA was significantly higher com- pared with that in female counterparts （ P 〈 0.01 ）. The incidence of HUA patients complicated with type 2 dia- betes mellitus, lipid metabolism disorder, hypertension and obesity was 26.2%, 58.3%, 60.6% and 12. 1% , and 27.5% , 59. 7%, 55.6% and 10.7% for gout counterparts. Dietary intake of salted noodle and animal lipid, hypertension and high levels of blood urea nitrogen were independent risk factors of the prevalence of HUA or gout in Meizhou area. Conclusions The prevalence of HUA and gout is relatively high. Restricting the intake of oil-cured salted noodle and animal lipid contributes to the prevention and treatment of HUA and gout in Meizhou area.

关 键 词：痛风 高尿酸血症 流行病学 危险因素 

分 类 号：R589.7[医药卫生—内分泌]