复方酮康唑凝胶促渗剂的筛选  

Penetration Enhancers Screening for Compound Ketoconazole Gel

作　　者：黄文涛[1] 周进[1] 

机构地区：[1]武汉市中西医结合医院药学部,武汉430022

出　　处：《中国药师》2016年第4期685-688,共4页China Pharmacist

基　　金：武汉市卫生局课题(编号:WX13D01)

摘　　要：目的:研究辛酸/癸酸甘油酯(Lab)、丙二醇(PG)以及氮酮(Azone)对复方酮康唑凝胶中酮康唑、硝酸咪康唑透皮行为的影响,筛选最佳促渗剂。方法:采用RYJ-6A型药物透皮扩散实验仪,考察不同浓度的Lab、PG、Azone对复方酮康唑凝胶中酮康唑、硝酸咪康唑透皮行为的影响。结果:3%PG的促渗作用最明显,使复方酮康唑凝胶中酮康唑渗透效果增加了2.004倍,硝酸咪康唑渗透效果增加了1.795倍,差异有统计学意义(P<0.05)。结论:3%PG的促渗效果明显,可应用于复方酮康唑凝胶制剂中。Objective： To study the effect of caprylic / capric acid glycerides（ Lab）,propylene glycol（ PG） and Azone on the transdermal behavior of ketoconazole and miconazole nitrate in compound ketoconazole gel,to screen appropriate penetration enhancers.Methods： Using a RYJ-6A-type transdermal drug diffusion tester,the effects of Lab,PG and Azone at different concentrations on the transdermal behavior of ketoconazole and miconazole nitrate in compound ketoconazole gel were studied. Results： 3% PG showed the most obvious penetration enhancement,which could increase the permeation of ketoconazole by 2.004 times,and increase the penetration of miconazole nitrate by 1. 795 times,and the differences were statistically significant（ P〈 0.05）. Conclusion： The penetration effect of 3% PG is obvious,which can be applied in compound ketoconazole gel.

关 键 词：促渗剂 酮康唑 硝酸咪康唑 复方酮康唑凝胶 

分 类 号：R944.9[医药卫生—药剂学]