清热止痛巴布剂基质处方的优化  

Optimization of Matrix Formula for Qingre Zhitong Cataplasm

作　　者：范彦博[1] 王薇[1] 杜雪光[1] 王进军[1] 

机构地区：[1]武汉市中医医院,武汉430014

出　　处：《中国药师》2016年第4期693-694,711,共3页China Pharmacist

基　　金：湖北省中医药中西医结合科研项目(编号:2008Z-Z04)

摘　　要：目的:优选清热止痛巴布剂的基质处方。方法:以持黏力和综合感官的综合评分为考察指标,选取聚丙烯酸钠、羧甲基纤维素钠、水合氯化铝和甘油的配比为考察因素,采用正交试验优选复方清热止痛巴布剂的基质处方。结果:清热止痛巴布剂的最佳基质处方配比为:聚丙烯酸钠-羧甲基纤维素钠-水合氯化铝-甘油=14∶1∶1∶120。结论:按优选的最佳基质处方制得的清热止痛巴布剂具有良好的持黏力与综合感官,工艺参数稳定可行。Objective： To optimize the matrix formula of Qingre Zhitong cataplasm. Methods： An orthogonal test was performed to study the matrix formula of Qingre Zhitong cataplasm with the comprehensive score of continued adhesion and integrated sensory as the evaluation indices and the ratio of sodium polyacrylate,carboxymethylcellulose sodium,aluminum chloride hydrate and glycerin as the influencing factor. Results： The optimal matrix formula of Qingre Zhitong cataplasm was as follows： the ratio of sodium polyacrylate,carboxymethylcellulose sodium,aluminum chloride hydrate and glycerin was 14 ∶1 ∶1 ∶120. Conclusion： Qingre Zhitong cataplasm prepared with the optimal matrix formula has good continued adhesion and integrated sensory,and the process parameters are stable and feasible.

关 键 词：巴布剂 基质 正交试验 

分 类 号：R283.6[医药卫生—中药学]