变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的临床对照研究  

Controlled Clinical Studies on Fluticasone Propionate Spray for Allergic Rhinitis Children Suffering with Adenoidal Hypertrophy

作　　者：吴莉[1] 姜妍[1] 沈莹[1] 

机构地区：[1]襄阳市中心医院耳鼻咽喉-头颈外科,湖北襄阳441021

出　　处：《中国药师》2016年第4期718-720,共3页China Pharmacist

摘　　要：目的：研究变应性鼻炎伴腺样体肥大患儿应用丙酸氟替卡松喷剂治疗的有效性和安全性。方法：选择变应性鼻炎伴腺样体生长的患儿160例做为观察组,其中腺样体肥大者109例;选择同期单纯腺样体生长的患儿157例做为对照组,其中腺样体肥大者114例。两组患儿均接受丙酸氟替卡松喷剂治疗3个月。观察比较两组患儿治疗前后鼻镜下腺样体体积、症状评分变化,以及药品不良反应发生情况。结果：变应性鼻炎伴随腺样体肥大患儿多发于3～6岁。治疗后,观察组有效腺样体缩小患者88例（80.73%）,显著多于对照组的67例（58.77%）（P〈0.01）;对照组治疗后腺样体肥大的患者为55例（35.03%）,明显多于观察组的44例（68.13%,P〈0.05）。治疗前后观察组患者的鼻塞症状积分差值、打鼾症状积分差值、张口呼吸症状积分差值显著大于对照组（P〈0.05）。结论：丙酸氟替卡松喷剂对于缩小变应性鼻炎伴腺样体肥大患儿腺样体体积比单纯腺样体肥大患儿更明显,且能更显著改善打鼾、鼻塞、张口呼吸症状。Objective： To research the efficacy and safety of fluticasone propionate spray for allergic rhinitis children suffering with adenoidal hypertrophy. Methods： Totally 160 allergic rhinitis with adenoids growth children were in the observation group,in which109 cases were diagnosed as adenoidal hypertrophy. Totally 157 adenoids growth children were in the control group,in which 114 cases were diagnosed as adenoidal hypertrophy. The two groups both received fluticasone propionate spray treatment for 3 months,and then the nasal endoscopic adenoidectomy volume,symptom score and adverse reactions were observed and analyzed. Results： Allergic rhinitis children suffering with adenoidal hypertrophy were mainly in the 3-6-year-old children. After the treatment,adenoids was shrinked in88 patients（ 80.73%） in the observation group,which was significantly higher than that in the control group [67（ 58.77%）,P〈0.01].Adenoidal hypertrophy was still in 44 patients（ 35.03%） of the observation group after the treatment,which was lower than that of the control group [55（ 68.13%）,P〈0.05]. In addition,the integral differences of nasal congestion,snoring and mouth breathing in the observation group after the treatment were higher than those in the control group,and the differences were statistically significant（ P〈0.05）.Conclusion： The efficacy of fluticasone propionate spray used in allergic rhinitis children suffering with adenoidal hypertrophy is more obvious than that in adenoid hypertrophy children,which can more significantly improve the symptoms of nasal congestion,snoring and mouth breathing.

关 键 词：丙酸氟替卡松 变应性鼻炎 腺样体肥大 

分 类 号：R977.11[医药卫生—药品]