子痫前期患者血清LCN-2的表达及其与病情的相关性分析  

Research and analysis of the expression of serum LCN-2 in patients with preeclampsia and its correlation with the disease

作　　者：白颖[1] 卢群[1] 李巧平[1] 任利容[1] 

机构地区：[1]深圳市宝安区妇幼保健院妇产科,广东深圳518000

出　　处：《中国医药科学》2016年第4期49-51,共3页China Medicine And Pharmacy

基　　金：广东省深圳市宝安区科技计划项目(2013081)

摘　　要：目的探讨子痫前期患者血清LCN-2的表达及其与病情的相关性进行研究分析。方法选取2013年1月~2015年6月深圳宝安区妇幼保健院接收的子痫前期患者100例,其中轻度子痫前期患者50例,作为轻度观察组,重度子痫前期患者50例,为重度观察组,同时选取健康正常孕妇50例,作为对照组,采用酶联免疫吸附试验法ELISA检测所有患者及健康对照组的血清LCN-2浓度并进行组间对比研究。结果轻度观察组的LCN-2浓度为（52.37±12.98）ng/m L,重度观察组患者的LCN-2浓度为（74.25±15.73）ng/m L,均明显高于健康对照组的（22.13±6.94）ng/m L,且各组之间进行比较差异有统计学意义（P〈0.05）。结论所有子痫前期患者的血清LCN-2浓度随着病情的严重程度均有不同程度的升高,病情越重,血清LCN-2浓度的升高程度越大,可作为子痫患者检测及判断病情的重要标志物,值得在临床上进行广泛推广应用。Objective To research and analyze the expression of serum LCN-2 in patients with preeclampsia and its correlation with the disease. Methods 100 patients with preeclampsia who were in Baoan District Maternal and Child Health Care Hospital from January 2013 to June 2015 were divided into two groups,50 patients with mild preeclampsia among them were assigned to mild group,other 50 patients with severe preeclampsia were assigned to severe group.Meanwhile,50 healthy pregnant women were selected as control group.Serum LCN-2 concentrations in all patients and healthy pregnant women were detected by enzyme-linked immunosorbent assay（ELISA）,and results between groups were compared. Results The LCN-2 concentration of the mild group was（52.37±12.98）ng/m L,the severe group＇s concentration was（74.25±15.73）ng/m L,both were significantly higher than that of the control group,which was（22.13±6.94）ng/m L.Compared between groups（P 0.05）,which was statistical significance. Conclusion The serum LCN-2 concentration in all preeclampsia patients increased with the aggravation of the disease.The more severe the disease was,the greater the level of serum LCN-2 concentration was.It can be used as an important evidence for the detection and diagnosis of preeclampsia,and is worthy to be widely used in clinical practice.

关 键 词：子痫前期 血清LCN-2 病情相关性 研究分析 

分 类 号：R714.256[医药卫生—妇产科学] R714.244[医药卫生—临床医学]