间歇性抗雄激素治疗前列腺疾病临床分析  

Analysis of intermittent antiandrogen therapy for prostate diseases in clinic

作　　者：赖俊彦[1] 孟祥军[1] 叶永康[1] 

机构地区：[1]广东省东莞市人民医院泌尿外科,广东东莞523000

出　　处：《中国医药科学》2016年第4期151-153,共3页China Medicine And Pharmacy

摘　　要：目的探讨间歇性抗雄激素治疗前列腺疾病临床效果。方法选取2012年1月~2015年3月我院收治58例晚期前列腺癌患者根据患者诊治顺序分为观察组和对照组,对照组采用手术去势联合持续性抗雄激素治疗,观察组采用药物去势联合间歇性抗雄激素治疗,比较治疗6个月后两组患者治疗效果、前列腺特异性抗原（PSA）水平、Gleason评分及不良反应发生情况。结果观察组治疗总有效率高于对照组（96.55%vs 75.85%,P〈0.05）;观察组患者血清PSA水平及Gleason评分均少于对照组,两组间各值比较有统计学意义（P〈0.05）;观察组治疗过程中潮热、乳房肿胀、腹泻、贫血及骨质疏松发生率低于对照组（17.24%vs48.28%,10.34%vs 44.83%,17.24%vs 65.52%,6.90%vs 34.48%,10.34%vs 41.38%,P〈0.05）。结论前列腺癌患者采用间歇性抗雄激素治疗可获得较高治疗效果和安全性。Objective To investigate the clinical effect of intermittent antiandrogen therapy in the treatment of prostate disease. Methods According to treatment order,58 patients with advanced prostate cancer who were in our hospital form January 2012 to March 2015 were divided into observation group and control group.The control group was treated with surgical castration combined with continuous antiandrogen therapy.The observation group was treated with drug castration combined with intermittent antiandrogen therapy.Then,therapy effects,prostate specific antigen（PSA） levels, Gleason scores,and adverse reactions of two groups after 6 months＇ treatment were compared. Results The total effective rate of the observation group was higher than that of the control group（96.55% vs 75.85%,P0.05）.The serum PSA level and Gleason score in the observation group were less than those in the control group. Comparison of values among two groups were statistically significant（P 0.05）.The incidence of hot flash, breast swelling, diarrhea,anemia, and osteoporosis in the observation group during treatment was lower than that of the control group（17.24% vs 48.28%,10.34% vs 44.83%,17.24% vs 65.52%,6.90% vs 34.48%,10.34% vs 41.38%,P 0.05）. Conclusion Intermittent antiandrogen therapy for patients with prostate cancer can obtain much better treatment effect and safety.

关 键 词：间歇性 抗雄激素 前列腺癌 前列腺特异性抗原 

分 类 号：R697.3[医药卫生—泌尿科学]