脓毒症诊断的生物学标志物的研究进展  

Progress of the Diagnosis of Sepsis on the Biological Markers

作　　者：李志华[1] 刘宣[1] 葛勤敏[1] 王海嵘[1] 潘曙明[1] 

机构地区：[1]上海交通大学医学院附属新华医院急诊科,上海200092

出　　处：《现代生物医学进展》2016年第7期1358-1362,共5页Progress in Modern Biomedicine

基　　金：上海市科委项目资助(13DZ19411003);上海市卫计委项目资助(2013SY038);国家临床重点专科建设项目资助

摘　　要：脓毒症是由致病微生物感染引发的全身炎症反应综合征(SIRS),合并血压降低且经快速液体复苏后血压仍不能恢复正常者称为脓毒性休克(Septic shock),其中一部分患者发展为多器官功能障碍综合症(MODS)。由于目前临床上仍缺乏早期敏感性诊断手段,脓毒症病死率居高不下。每10万人口中约50-300人会发生严重脓毒症,其短期死亡率达20%-25%,当发展为脓毒性休克时其死亡率达50%。随着分子生物学和现代生物技术的不断发展,人们发现多种生物标志物在脓毒症的早期诊断、病情及预后判断,疗效评估中发挥重要作用。因此深入了解脓毒症病理生理机制中不同生物标志物的意义及价值,对于脓毒症及其并发症的早期识别及干预,降低患者病死率及改善患者生活质量有积极意义。本文综述了近几年来对脓毒症的诊断和预后有一定价值的主要标志物及其应用。Human sepsis is thought to be systemic inflammatory response syndrome（SIRS） that is activated by invasive infection. It can rapidly develop into sever sepsis, septic shock and multiple organ dysfunction（MODS）. Due to lacking of sensitive diagnosis methods, severe sepsis places a large burden on health care systems, with an incidence ranging from 50 to 300 cases and a short-term mortality of 20 % to 25 %, reaching up to 50 % when shock is present. With the development of molecular biology and biotechnology,many biological markers were researched about their functions of the early diagnosis of sepsis, the judge of severity and the prognostic of the disease. Therefore, it is good for the patients to reduce the mortality and improve the life quality if the researchers know the value of different biological markers. Here, we review the progress of different biological markers for the early diagnosis of sepsis.

关 键 词：脓毒症 脓毒症早期诊断 预后 生物标志物 

分 类 号：R631.2[医药卫生—外科学]