幽门螺杆菌基因分型与胃病关系研究进展  

Research Progression on Association of Helicobacter pylori Genotype with Stomach Disease

作　　者：刘贤[1] 何帮顺[1] 林康[1] 陈杰[1] 彭红新 王书奎[1] 

机构地区：[1]南京医科大学附属南京医院中心实验室,江苏南京210006

出　　处：《现代生物医学进展》2016年第7期1390-1393,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81172141)

摘　　要：幽门螺旋杆菌(Helicobacter pylori,Hp)已被国际癌症组织确认为胃部疾病最主要的致病因子。近年来对于Hp菌株的基因分型、流行病学和致病性等方面的研究逐步深入,越来越多的研究成果证实对Hp基因分型进行细化可为精准医疗提供依据。Hp可依照Cag A羧基末端磷酸化位点、Vac A信号区(s)中间区(m)过渡区(i)缺失区(d)和粘附因子(OMPs)进行基因分型。Hp基因型差异可导致不同毒性作用,从而引起不同临床结果和疗效预后。因此对Hp基因分型可为胃病的防治提供重要依据。本文就Hp基因分型方法、基因分型及其与胃部疾病研究进展进行如下综述。Helicobacter pylori（Hp） has been recognized as the main pathogenic factor for stomach diseases by the international organization for cancer. In recent years, more and more studies confirmed that the evidence for Precision Medical can be provided with gradual deepening study on Hp genotype and epidemiology as well as pathogenesis. Hp can be genotyped by Cag A carboxyl terminal phosphorylation sites, VacA signal area（s）, middle area（m） intermediate area（I） and adhesion factor（OMPs）. The difference of Hp genotype can cause different toxic effects, which lead to different clinical outcome, curative effect and prognosis. So Hp genotyping can provide important basis for prevention and treatment of gastric disease. Hence, we performed this study to comprehensively review the progression in method and genotyping of Hp, and association between its genotype and stomach diseases.

关 键 词：幽门螺杆菌 基因分型 Cag-PAI VACA 

分 类 号：R37[医药卫生—病原生物学] R573[医药卫生—基础医学]