右美托咪啶对苏醒期小儿血清肌钙蛋白I、C反应蛋白及补体的影响  

Effect of Different Concentration of Dexmedetomidine on the Level of Serum Troponin I, C Reactive Protein and Complement after Anesthesia in Children

作　　者：朱敦[1] 官彬[1] 关正[1] 谭静[1] 朱宇麟[1] 

机构地区：[1]西安交通大学第一附属医院麻醉科,陕西西安710043

出　　处：《现代生物医学进展》2016年第8期1483-1486,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(2012SM77)

摘　　要：目的：探究不同浓度右美托咪啶对小儿麻醉后肌钙蛋白I、C反应蛋白以及补体变化的影响。方法：收集我院下腹股沟斜疝、急性阑尾炎以及肠套叠手术患儿75例,根据治疗方法不同分为三组,每组25例,其中A组实施0.5μg/kg负荷剂量右美托咪啶治疗,B组实施0.25μg/kg负荷剂量右美托咪啶治疗,C组实施右美托咪啶0.2~0.7μg/kg/h持续泵入。对比三组患者苏醒情况、血清肌钙蛋白I、C反应蛋白、补体水平、镇定及躁动评分。结果：手术后,B组自主呼吸恢复时间、气管导管拔管时间、解除监护时间明显缩短,且与其他两组比较,差异有统计学意义（P〈0.05）;与A、C两组相比,B组手术后C反应蛋白及血清肌钙蛋白I水平较低,而C3及C4水平较高,差异具有统计学意义（P〈0.05）;B组镇静、躁动评分明显降低,差异有统计学意义（P〈0.05）。结论：0.25μg/kg负荷剂量右美托咪啶能够有效减轻患儿术后炎性反应,缓解麻醉后神经损伤,有助于脏器功能的恢复。To explore the different concentrations of dexmedetomidine on the level of serum troponin I, C protein and complement after anesthesia in children. Methods： 75 cases with inguinal hernia, acute appendicitis and intussusception in children were collected in our hospital, and divided into three groups according to the different treatment methods, 25 cases in each group. The children in group A were given a implementation 0.5 μg/kg loading dose dexmedetomidine treatment and the children in group B were treated with implementation of 0.25 μg/kg loading dose dexmedetomidine and the children in group C received continuous bump injection of dexmedetomidine from 0.2 to 0.7 μg/kg/h. The situation of postanaesthetic recovery, and the serum level of troponin I, C reactive protein,complement, and the sedation and agitation scale was recorded and compared among three groups. Results： After operation, the recovery time of spontaneous breathing, the time of extubation, and the time of release in group B was significantly shorter than that of the other two groups, and the difference was statistically significant（P〈0.05）. Compared with group A and group C, the level of C reaction protein and serum troponin I was lower in group B, and the level of C3 and C4 was higher, and the differences were statistically significant（P〈0.05）; Compared with group A and group C, the sedation and restlessness score was lower in group B with statistical significance（P〈0.05）. Conclusions： 0.25 μg/kg dexmedetomidine can effectively relieve the inflammatory reaction after surgery in children, alleviate nerve injury and contribute to the recovery of visceral function.

关 键 词：右美托咪啶 小儿麻醉 肌钙蛋白I C反应蛋白 补体 

分 类 号：R614[医药卫生—麻醉学]