miRNA参与肿瘤基因表达调控研究进展  

Advances in the Research of Correlation between mi RNA and gene Regulation in Tumor

作　　者：孙晓琴[1,2] 易山[1] 牛香莲 米锴[1] 孙茂盛[1] 

机构地区：[1]中国医学科学院北京协和医学院医学生物学研究所云南省重大传染病疫苗研发重点实验室,云南昆明650118 [2]昆明医科大学,云南昆明650031

出　　处：《现代生物医学进展》2016年第8期1551-1554,共4页Progress in Modern Biomedicine

基　　金：国家863项目(2012AA02A404);重大新药创制专项(2014ZX09102041004);云南省应用基础研究计划面上项目(2009CD142)

摘　　要：调查表明,我国城乡居民恶性肿瘤死亡率属于世界较高水平,而且呈持续的增长趋势。近年来的研究发现在肿瘤的发生与发展过程中涉及到多种因素,其中mi RNA可能扮演了重要的作用。mi RNA是一种长度约为22 nt的非编码短序列RNA,通过介导特异性的基因沉默导致靶m RNA降解,促使相应蛋白质的转译受阻而失去原有编码蛋白质的功能。mi RNA在细胞分裂周期中影响着基因的表达调控,在此过程中基因表达的失控就可能导致疾病的发生。而肿瘤的发生是以细胞恶变为基础,细胞恶变则是与细胞周期调控因素失衡相关,由此提示了一些mi RNA可能参与了肿瘤的发生、发展过程并在其中发挥了重要作用。随着研究的深入,mi RNA逐渐成为肿瘤诊治的新研究方向。本文主要讨论mi RNA在肿瘤基因表达调控方面的研究进展。The results of the survey demonstrate that the malignant tumor mortality of urban and rural residents belongs to the higher level and the continued growth trend in our country. In recent years, researches has found that mi RNA plays an important role in the process of the occurrence and development of tumor. Mi RNA is a kind of small non-coding RNA with about 22 nucleotides, which participates in regulating gene expression at the post-transcriptional leve1.Post-transcriptional silencing of target genes by mi RNA occurs either by targeting specific cleavage of m RNA or by targeting specific protein synthesis. Mi RNA can regulate the gene expression in cell cycles, which dysfunction often lead to human disease. The occurrence of tumor is based on cell malignant transformation, which is related to the regulating factor of cell cycle unbalanced. This suggesting that some mi RNAs may participate in the occurrence and development process of tumor and play a key role.With the deepening of the research, mi RNA will become the new direction for diagnosis and treatment of tumor. In this review, I will discuss the progress in the study on mi RNA in gene regulation of cancer.

关 键 词：MI RNA 肿瘤 基因表达调控 

分 类 号：Q74[生物学—分子生物学] Q75