复发性风湿症患者不良预后的影响因素的研究  

Research on the Influence Factors of Poor Prognosis in Patients with Recurrent Rheumatism

作　　者：温艳芳[1] 陈剑锋[1] 廖湘平[1] 肖华[1] 

机构地区：[1]湖南省郴州市第一人民医院,湖南郴州423000

出　　处：《中国医学创新》2016年第10期4-7,共4页Medical Innovation of China

摘　　要：目的：了解抗环瓜氨酸肽（CCP）抗体及发作频率对复发性风湿症（PR）患者发展为类风湿关节炎（RA）的影响。方法：分析2010年1月-2015年1月本院收治的复发性风湿症患者的临床及实验室资料,按照患者就诊时CCP检查结果分为CCP抗体阳性组5例,阴性组18例;按患者发作频率分为高频率发作组（发作频率≥12次/年）7例,低频率发作组（发作频率〈12次/年）16例。对所有患者随访1~5年,分别比较CCP阳性组与阴性组、高频率发作组与低频率发作组发展为RA的患者比例。结果：CCP阳性组1例发展为RA（20.0%）,CCP阴性组2例发展为RA（11.1%）,两组发展为RA的患者比例比较,差异无统计学意义（P〉0.05）;高频率发作组中3例发展为RA（42.9%）;低频率发作组均未发展为RA。高频率发作组发展为RA的患者比例高于低频率发作组,比较差异有统计学意义（P〈0.05）。结论：高频率发作的复发性风湿症患者发展为RA的风险高于低频率发作的患者,这部分患者需要更积极的治疗干预。CCP抗体对复发性风湿症是否发展为RA的意义待定。Objective：To study whether the attack frequency and anti-cyclic citrullinated peptide（CCP） antibodies are risk factors for patients with palindromic rheumatism（PR） progressed to rheumatoid arthritis（RA）.Method：Twenty-three patients with PR from January 2010 to January 2015 were selected and devided into 5 patients of positive CCP group and 18 patients of negative CCP group,7 patients of high attack frequency group（attcks≥12 times per year） and 16 patients of low attack frequency group（attcks12 times per year） separatelyafter their clinical and laboratry datas were analyzed.Each patient was followed up for 1-5 years,and the probability of developing to RA between the positive CCP and negative CCP group,the high attack frequency and the low attack frequency group were compared respectively.Result：One patient developed to RA（20.0%）in the positive CCP group,while two patients developed to RA in the negative CCP group（11.1%）,the difference between the two groups was not statistically significant（P〉0.05）.Three patients developed to RA in the high attack frequency group（42.9%） and none in the low attack frequency group,the proportion of patients developing into RA in the high attack frequency group was higher than that in the low attack frequency group,the difference was statistically significant（P〈0.05）.Conclusion：The probability of developing to RA in patients with high attack frequency PR is higher than that in patients with low attack frequency,patients with high attack frequency PR need more active treatment intervention.The meaning of CCP antibodies for PR developing to RA is still to be determined.

关 键 词：复发性风湿症 抗环瓜氨酸肽抗体 发作频率 

分 类 号：R593.22[医药卫生—内科学]