基于文本挖掘的胃癌前病变当代中医药学术团队研究热点及趋势分析  

Contemporary view and trends analysis on clinical research of traditional Chinese medicine academic team about precancerous lesions of CAG based on text mining technique

作　　者：王海燕[1] 黎元元[2] 谢雁鸣[2] 王志飞[2] 

机构地区：[1]北京友谊医院,北京100050 [2]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中华中医药杂志》2016年第4期1198-1202,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点基础研究发展计划(973计划)(No.2013CB532004)~~

摘　　要：目的:分析胃癌前病变当代中医药临床研究学术团队的基本学术观点,为教学、科研、临床工作提供参考和量化信息支持。方法:在中国生物医学文献数据库中检索近30年"胃癌前病变"的中医药学术论文并下载题录,应用正则表达式提取作者信息,根据普赖斯定律确定高产作者群,应用Net Draw软件构建高产作者合作关系图,分析其核心人物;通过H指数评估其学术影响力,筛选重要学术团队;研读各团队核心人物的代表文章,总结其学术思想。结果:共检索到相关文献2 499篇,涉及高产作者62人,筛选出重要学术团队9个,各团队核心思想中对胃癌前病变的病机认识均为本虚标实;不同团队对本虚的认识均为气虚、气阴虚为主导致的中焦气机不畅;对标识的认识各有侧重,9个团队均强调血瘀在胃癌前病变中的重要病理作用,其中4个团队同时强调毒邪在疾病中的重要作用,1个团队明确指出毒邪即为幽门螺旋杆菌。在遣方用药方面,活血化瘀药多用丹参、莪术等,部分团队重视虫类及动物类药物的应用。结论:胃癌前病变当代中医药学术观点较统一,都强调补虚是根本,应贯彻始终,同时应化瘀祛毒标本兼治,但在遣方用药方面存在较大差异。Objective： To analyze the contemporary academic team of traditional Chinese medicine clinical research about precancerous lesions of chronic atrophic gastritis（CAG）, to sum up the basic point of view of each academic team, and to provide a reference for teaching, scientific research and clinical work and quantitative information support. Methods： All the academic papers of ‘gastric precancous lesion＇ over the past 30 years in Chinese biomedical literature database were collected. The author information were extracted by regular expressions. The high yield authors were determined according to the price law, and the high-yield authors relationship diagram were analyzed by Net Draw software. Their academic influence were assessed through the index H, and the key academic teams were screened. The articles written by the core leader of the team were summarized, and the academic thought were summed up. Results： A total of 2 499 related literature involving 62 main contributors were retrieved, and 9 important academic teams were selected. In the aspect of pathological changes, the common knowledge of precancerous lesions of CAG of each team was deficiency of root cause and excess of manifestation; the common knowledge of deficiency of root cause was disorder of qi movement of middle jiao caused by deficiency of qi or deficiency of both qi and yin. Nine teams agreed that blood stasis was an important pathological change of precancerous lesions of CAG, four of the teams emphasized the important role of toxin factors, and one of the team clearly pointed out that toxin factor was helicobacter pylori. In the aspect of medication, the common medicines for promoting blood circulation for removing blood stasis were Radix Salviae Miltiorrhizae and Rhizoma Curcumae etc. Some teams attached great importance to the application of insect and animal medicine. Conclusion： Contemporary academic point of view of traditional Chinese medicine about precancerous lesions of CAG is unified. The fundamental treatment is supply

关 键 词：胃癌前病变 普赖斯定律 学术团队 病机 幽门螺旋杆菌 慢性萎缩性胃炎 

分 类 号：R259[医药卫生—中西医结合]