普外科病原菌耐药率与β-内酰胺类药物使用强度的关系  

Relationship between resistance rate of pathogen and utilization strength of β-lactam in general surgery department

作　　者：方圆[1] 陈涛[2] 李晓华[1] 刘平[1] 陈楠[1] 

机构地区：[1]南方医科大学附属郑州人民医院药学部,河南郑州450003 [2]南方医科大学附属郑州人民医院普外科,河南郑州450003

出　　处：《中国医药科学》2016年第3期25-28,共4页China Medicine And Pharmacy

摘　　要：目的评价普外科病原菌耐药变化趋势与β-内酰胺类用量间的关系。方法统计2012~2014年检出主要病原菌耐药率及β-内酰胺类使用强度,运用统计软件分析两者的相关性。结果头孢唑肟使用强度与大肠埃希菌、肺炎克雷伯菌耐药率间均有相关性,头孢吡肟与肺炎克雷伯菌对其耐药率间有相关性,哌拉西林他唑巴坦使用强度与肠杆菌科耐药率间无相关性,所有监测品种均与铜绿假单胞菌耐药率间有相关性。结论肠杆菌科细菌仍是普外科治疗感染的重点。普外科慎重选择三代头孢治疗肠杆菌科细菌感染,对有感染产ESBLs肠杆菌科细菌风险的患者,可选择哌拉西林他唑巴坦。Objective To evaluate the relationship between the resistance change trend of pathogen and the dosages of β-lactam in general surgery department. Methods To make statistics and to analyze the relationship on the resistance rate of main pathogen and the utilization strength of β-lactam, which were detected from 2012 to 2014, applied the statistical software. Results There were correlation between the utilization strength of ceftizoxime and the resistance rate of escherichia coli and klebsiella pneumonia, between the utilization strength of cefepime and the resistance rate of klebsiella pneumonia, there was no correlation between the utilization strength of piperacillintazobactam and the resistance rate of enterobacteriaceae, there was correlation all monitoring cultivated varieties and the resistance rate of pseudomonas aeruginosa. Conclusion Enterobacteriaceae is also the key point of infection treatment in general surgery department. The third generation cephalosporin in the treatment of bacterial infection of enterobacteriaceae is chosen carefully in general surgery department. Piperacillin-tazobactam should be chosen on patients with the ESBLs risk of enterobacteriaceae.

关 键 词：普外科 感染 耐药率 Β-内酰胺 

分 类 号：R95[医药卫生—药学]