早产儿支气管肺发育不良临床高危因素分析  

Risk Factors of Bronchopulmonary Dysplasia in Preterm Infants

作　　者：岳伟红[1] 

机构地区：[1]重庆医科大学附属儿童医院,重庆400014

出　　处：《儿科药学杂志》2016年第4期16-19,共4页Journal of Pediatric Pharmacy

摘　　要：目的:探讨影响不同分度早产儿支气管肺发育不良(BPD)的临床高危因素,为临床防治提供参考。方法:选取重庆医科大学附属儿童医院2013-2014年收治的BPD早产儿81例,按照临床分度标准分为轻度组24例和中重度组57例,对其围产期情况、母孕期情况、合并症、临床治疗及预后情况进行回顾性分析。结果:中重度组呼吸窘迫综合征(RDS)、呼吸衰竭、动脉导管未闭(PDA)、先天性心脏病、肺出血、消化道出血的患儿比例高于轻度组,机械通气时间长于轻度组,日增长体质量低于轻度组(P均<0.05)。两组在性别、胎龄、胎数、出生体质量、母亲年龄、产前激素及出生后肺表面活性剂的应用等方面比较差异均无统计学意义(P均>0.05)。结论:积极防治RDS、肺出血、消化道出血、PDA等合并症是减少早产儿BPD的关键,尽可能缩短机械通气时间是重要措施之一。Objective： To investigate the clinical risk factors of premature infants with different severities of BPD,and to provide reference for the prevention and treatment of BPD in preterm infants. Methods： A total of 81 preterm infants who were admitted to NICU in the Children＇s Hospital of Chongqing Medical University from 2013 to 2014 were analyzed retrospectively. The history of birth and mother pregnancy,clinical treatment,prognosis and complication of mild,moderate and severe BPD according to clinical diagnostic criteria were analyzed retrospectively. Results： In the total 81 premature infants,24 cases were diagnosed as mild BPD. Fifty seven cases were moderate and severe BPD. With the increasing severity of BPD,RDS,PDA,respiratory failure,pulmonary hemorrhage,gastrointestinal hemorrhage and mechanical ventilation time were increasing,and the daily increased weight was decreaced（ P〈0.05）.Conclusion： Preventing and reducing complications as RDS,PDA,pulmonary hemorrhage and gastrointestinal hemorrhage,shorten the duration of mechanical ventilation are the key factors to reduce severities of BPD in preterm infants.

关 键 词：支气管肺发育不良 危险因素 早产儿 

分 类 号：R722.6[医药卫生—儿科]