Synthesis and Bioactivity of a Novel Bismuthoxide Schiff-base Complex Derived from Salen-like Ligand and Bismuth（III） Nitrate  

作　　者：LI Chuanhua JIANG Jianhong LI Xu XIAO Shengxiong WEI Deliang JIANG Chao XIE Jinqi PENG Mengna GU Huiwen LI Qiangguo 

机构地区：[1]Hunan Provincial Key Laboratory of Xiangnan Rare-precious Metals Compounds and Applications, Department of Chemistry and Life Science, Xiangnan University, Chenzhou 423000, P. R. China [2]State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering Hunan University, Changsha 410082, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第2期207-211,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（Nos.21273190, 20973145） and the Science and Technology Plan Projects of Hunan Province, China（Nos.2014F J3011, 2013F J3033, 2014TT2026）.

摘　　要：In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（CH3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene bis（3-methoxysalicylideneimine）] and bismuth（III） nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaecharomyees pombe（S, pombe） were studied using biological mierocalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 ℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant（k）, inhibition ratio（I） and half inhibition concentration（IC50） were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.In this paper, a novel bismuthoxide Schiff-base complex [Bi9O8（vanen）3（NO3）2（CH3OH）2（H2O）·3NO3· 5.5H2O]（abbreviated as Bivanen） was synthesized with Salen-like ligand Hzvanen[Hzvanen=N,N＇-ethylene bis（3-methoxysalicylideneimine）] and bismuth（III） nitrate. Its structure was characterized by IR spectra, NMR spectra and X-ray diffraction. In particular, the biology activities of the ligand and the complex against Schizosaecharomyees pombe（S, pombe） were studied using biological mierocalorimetry. The metabolic thermogenic curves of S. pombe were measured at 32.00 ℃. Then, some quantitative thermokinetic parameters of growth metabolism of S. pombe including the rate constant（k）, inhibition ratio（I） and half inhibition concentration（IC50） were calculated. Experimental results showed that the k values of S. pombe decreased while I values of S. pombe increased with the increase of concentrations of the ligand and the complex. The IC50 of the ligand and the complex were found to be 0.067 and 0.037 mmol/L, respectively.

关 键 词：Bismuthoxide Schiff-base complex Mieroealorimetriy Thermokinetie property Schizosaecharomyces pombe（S  pombe） 

分 类 号：O635.2[理学—高分子化学] TQ246[理学—化学]