Functional β-Cyclodextrin Coating by Electrodeposition on Stainless Steel for Drug Loading and Release  

作　　者：CHEN Bin CHEN Jie YANG Liming ZHAO Guochen DING Guowei 

机构地区：[1]School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China [2]Department of Oral and Maxillofacial Surgery, Tongji Hospital, Tongji University, Shanghai 200065, P. R. China

出　　处：《Chemical Research in Chinese Universities》2016年第2期278-283,共6页高等学校化学研究（英文版）

摘　　要：β-Cyclodextrin（β-CD） can be used for drug loading and release in biomedical application, β-Cyclodextrin- salicylate（β-CD-S） was synthesized by transesterification and then was electrodeposited on the surface of stainless steel（SS） by the anodic electrooxidation polymerization of the salicylate. 1H NMR spectrometry was used to determine the structure offl-CD-S. FTIR spectroscopy and XPS were applied to verifying the synthesized β-CD-S and the existence of the electrodeposited layer on the SS surface, respectively. Tafel plots and electrochemical impedance spectroscopy（EIS） technologies were used to estimate the corrosion resistance of β-CD-covered stainless steel. Electrochemical quartz crystal microbalance was applied to determining the drug loading of the stainless steel before and after its modification. E. coli was selected as a harmful microbe to evaluate the antibacterial properties of the stainless steel with the comparison of optical density values.β-Cyclodextrin（β-CD） can be used for drug loading and release in biomedical application, β-Cyclodextrin- salicylate（β-CD-S） was synthesized by transesterification and then was electrodeposited on the surface of stainless steel（SS） by the anodic electrooxidation polymerization of the salicylate. 1H NMR spectrometry was used to determine the structure offl-CD-S. FTIR spectroscopy and XPS were applied to verifying the synthesized β-CD-S and the existence of the electrodeposited layer on the SS surface, respectively. Tafel plots and electrochemical impedance spectroscopy（EIS） technologies were used to estimate the corrosion resistance of β-CD-covered stainless steel. Electrochemical quartz crystal microbalance was applied to determining the drug loading of the stainless steel before and after its modification. E. coli was selected as a harmful microbe to evaluate the antibacterial properties of the stainless steel with the comparison of optical density values.

关 键 词：Β-CYCLODEXTRIN Surface modification Stainless steel Drug release ELECTRODEPOSITION 

分 类 号：O636.12[理学—高分子化学] TB611[理学—化学]