金樱根化学成分研究(Ⅰ)  

The chemical constituents from the roots of Rosa laevigata Michx.( Ⅰ)

作　　者：汪玉梅[1] 苏贤君 符崖[1] 王志芳[1] 张翠仙[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《中山大学学报（自然科学版）》2016年第2期76-80,84,共6页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：广东省科技计划重点资助项目(2010A03010003);广东省分析测试技术公共实验室开放课题资助项目(001);2015年高水平大学建设专项资金资助项目(2050205)

摘　　要：前期研究表明广东凉茶颗粒中三萜皂苷主要来源于岗梅和金樱根。而目前对于金樱根化学成分研究主要集中在金樱子叶和果实,对其根化学成分研究鲜见报道。基于此,该实验在前期基础上采用正反相硅胶、凝胶等多种分离手段对金樱根甲醇提取物的乙酸乙酯相化学成分进行研究,从中分离得到了6个化合物,采用现代波谱分析和文献对照等方法鉴定其结构分别为:2α,3α,19α-三羟基乌苏-12-烯-28-酸28-O-β-D-吡喃葡萄糖苷(1)、2α,3β,19α-三羟基乌苏-12-烯-28-酸28-O-β-D-吡喃葡萄糖苷(2)、2α,3β,19α,23-四羟基乌苏-12-烯-28-酸28-O-β-D-吡喃葡萄糖苷(3)、齐墩果酸(4)、熊果酸(5)、(+)-儿茶素(6)。化合物1,2,3为首次从金樱根中分离得到,且为广东凉茶颗粒中三萜皂苷类成分。Previous experiments showed that triterpenoid saponins of Guangdong Liangcha were mainly from the roots of ilex asprella and Rosa laevigata Michx.. However,chemical constituents mainly focus on leaves and fruits of Rosa laevigata Michx.,and the secondary metabolites from the roots of Rosa laevigata Michx. were very few published. So,on the basis of previous study,six compounds were isolated from the roots of Rosa laevigata Michx. by various chromatographic techniques and their structures were identified by spectroscopic analysis and literature confrontation method,such as 2α,3α,19α-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester（ 1）,2α,3β,19α-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester（ 2）,2α,3β,19α,23-tetrahydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester（ 3）,oleanolic acid（ 4）,ursolic acid（ 5）,（ ＋）-catechin（ 6）. Compounds 1,2,3 as triterpenoid saponins in Guangdong Liangcha have been firstly obtained from the roots of Rosa laevigata Michx..

关 键 词：金樱根 化学成分 三萜及其苷类 结构鉴定 

分 类 号：O629.7[理学—有机化学] R284.2[理学—化学]