Multiple amino acid sensing inputs to mTORC1  

作　　者：itsugu Shimobayashi Michael N Hall 

机构地区：[1]Biozentrum, University of Basel, Basel, Switzerland

出　　处：《Cell Research》2016年第1期7-20,共14页细胞研究（英文版）

基　　金：Acknowledgments We acknowledge support from the Louis-Jeantet Foundation, the Swiss National Science Foundation and the Canton of Basel.

摘　　要：The evolutionarily conserved target of rapamycin complex 1 （TORC1） is a master regulator of cell growth and metabolism. In mammals, growth factors and cellular energy stimulate mTORC1 activity through inhibition of the TSC complex （TSC1-TSC2-TBC1D7）, a negative regulator of mTORC1. Amino acids signal to mTORC1 independently of the TSC complex. Here, we review recently identified regulators that link amino acid sufficiency to mTORC1 activity and how mutations affecting these regulators cause human disease.

关 键 词：mTORC1 amino acid RAG 

分 类 号：Q517[生物学—生物化学] TP334.23[自动化与计算机技术—计算机系统结构]