神经节苷酯钠治疗急性重症颅脑损伤的临床疗效研究  

Clinical efficacy of ganglioside in treatment of acute severe craniocerebral injury

作　　者：周婷[1] 张平[1] 张莉[2] 宋凌霞[1] 李大芬[1] 贺建湘[1] 冯翼[1] 

机构地区：[1]遵义医学院附属医院神经外科,贵州遵义563003 [2]遵义医学院附属医院护理部,贵州遵义563003

出　　处：《中国临床药理学杂志》2016年第7期582-584,共3页The Chinese Journal of Clinical Pharmacology

基　　金：贵州省科学技术基金资助项目(黔科合J字【2013】2330号)

摘　　要：目的观察神经节苷酯钠治疗急性重症颅脑损伤的临床疗效。方法将90例急性重症颅脑损伤患者随机分为对照组45例和试验组45例。对照组予以静脉滴注5 mL·kg^(-1)20%甘露醇,30 min完毕+0.4 mg·kg^(-1)呋塞米+纳洛酮8 mg+醒脑静注射液20 mL+注射用血凝酶1 kU,连续治疗8周。试验组在对照组的基础上,加用静脉滴注神经节苷脂钠注射液100 mg,连续治疗2周后,改为40 mg·d^(-1)维持治疗6周。比较2组患者的炎性因子、凝血功能及预后情况。结果治疗后,试验组的降钙素基因相关肽明显高于对照组,肿瘤坏死因子、内皮素明显低于对照组(P<0.05);试验组的凝血酶时间明显低于对照组,纤维蛋白原明显高于对照组(P<0.05),但2组患者的血小板、凝血酶原时间、活化部分凝血酶时间等指标比较差异无统计学意义(P>0.05)。试验组的预后良好率为46.67%,明显高于对照组22.22%(P<0.05)。结论神经节苷酯钠治疗急性重症颅脑损伤有助于缓解炎性症状,改善凝血功能,提高临床疗效。Objective To evaluate the clinical efficacy of early application of ganglioside in the treatment of acute severe craniocerebral injury,and to put forward nursing measures. Methods Ninety cases of patients with acute severe craniocerebral injury were randomly divided into control group（ n = 45） and treatment group（ n = 45）. Control group was given the treatment of 5 mL·kg^-1 20% mannitol,30 min infusion is completed,0. 4 mg·kg^-1 furosemide,naloxone 8 mg,Xingnaojing injection 20 mL,hemocoagulase 1 kU,continuous treatment for 8 weeks. Treatment group was given ganglioside injection 100 mg,continuous treatment for 2 weeks,and reduced the dose to 40 mg for maintenance therapy at next 6 weeks. The inflammatory factor,coagulation function and prognosis of two groups were compared between two groups. Results After treatment,calcitonin gene- related peptide in treatment group was significantly higher than that of control group,tumor necrosis factor- α,endothelin- l were significantly lower than those of control group（ P〈0. 05）. Thrombin time of treatment group was significantly lower than that of control group,fibrinogen was significantly higher than that of control group（ P〈0. 05）,the differences of platelets,prothrombin time,activated partial thromboplastin time and other indicators between two groups were not statistically significant（ P〉0. 05）. Good prognosis rate in treatment group was significantly higher than that of control group（ 46. 67% vs 22. 22%,P〈0. 05）. Conclusion Ganglioside helps to alleviate inflammatory symptoms,improve coagulation function,and improve the effect of treatment. Strengthening the nursing intervention can effectively improve the prognosis of patients.

关 键 词：急性重症颅脑损伤 神经节苷酯钠 炎性因子 凝血功能 

分 类 号：R97[医药卫生—药品]