白芍总苷对类风湿关节炎患者的血脂影响  

Efficacy of total glucosides of paeonia on blood lipid in patients with rheumatoid arthritis

作　　者：张虹[1] 范宏涛[1] 

机构地区：[1]云南省第一人民医院风湿免疫科,昆明650000

出　　处：《中国临床药理学杂志》2016年第7期597-599,共3页The Chinese Journal of Clinical Pharmacology

基　　金：云南省应用基础研究计划基金资助项目(2010zc205)

摘　　要：目的观察白芍总苷对类风湿关节炎血脂影响。方法将类风湿关节炎患者随机分成对照组43例和试验组43例,2组患者均口服甲氨蝶呤7.5 mg,每周一次,口服来氟米特10 mg,每日一次。在此基础上,试验组加用白芍总苷0.6g,每日1次。2组疗程均为3个月。用EHK-40红细胞沉降压积仪检测2组患者治疗前后的血沉(ESR),散射免疫比浊法检测C-反应蛋白(CRP),酶联免疫吸附法测定类风湿因子(RF),全自动生化仪测定血清总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及三酰甘油(TG)。结果对照组,胃肠道反应发生率和食欲下降率均明显高于试验组(P<0.05);治疗后,2组的TC、HDL-C、LDL-C、TG较治疗前有明显改善(均P<0.05)。治疗后,试验组生化指标改善程度明显高于对照组(P<0.05)。治疗后,2组患者的晨僵时间、关节压痛指数、关节肿胀指数、CRP、RF及ESR均较治疗前有改善(均P<0.05)。治疗后,试验组:晨僵时间、关节压痛指数、关节肿胀指数、CRP、RF、ESR分别为(28.9±11.4)min、(9.3±3.4)mg·L^(-1)、(6.7±2.8)mg·L^(-1)、(20.3±8.7)mg·L^(-1)、(104.5±3.5)u·mL^(-1)、(22.1±3.5)mm·h^(-1);对照组分别为(34.6±13.6)min、(11.7±4.1)mg·L^(-1)、(8.5±3.5)mg·L^(-1)、(24.7±11.3)mg·L^(-1)、(116.7±5.6)μ·mL^(-1)、(27.8±4.2)mm·h^(-1),试验组改善程度明显优于对照组(P<0.05)。结论白芍总苷对类风湿关节炎患者血脂有改善作用。Objective To investigate the effect of total glucosides of paeonia（ TGP） on blood lipid in patients with rheumatoid arthritis.Methods Eighty- six cases of rheumatoid arthritis patients were randomly divided into control group and treatment group,43 cases in each group. The patients in control group were orally given methotrexate 7.5mg,once a week,and leflunomide 10 mg orally once daily. On the basis of control group,patients in treatment group were orally given TGP in dose of 0.6 g,once daily. The treatment lasted for three months. Erythrocyte sedimentation rate（ ESR） was determined. The C- reactive protein（ CRP） was determined by nephelometric immunoassay assay. The rheumatoid factor was determined by enzyme- linked immunosorbent assay. The total cholesterol（ TC）,high density lipoprotein（ HDL- C）,low- density lipoprotein（ LDL- C）,and triglyceride（ TG） in serum were determined by full automatic biochemical analyzer. Results In the control group, the incidence of gastrointestinal reactions and loss ofappetite were significantly higher than that in the treatment group（ P〈0. 05）. The TC,HDL- C,LDL- C,TG in two groups were improved significantly compared with those before treatment（ all P〈0. 05）. The degree of improvement on TC,HDL- C,LDL- C,TG in the treatment group was significantly higher than that in control group after treatment（ P〈0. 05）. After treatment,the duration of morning stiffness,joint tenderness index,joint swelling index,CRP,rheumatoid factors（ RF）,and erythrocyte sedimentation（ ESR） in two groups are improved compared with those before treatment（ P〈0. 05）. The duration of morning stiffness,joint tenderness index,joint swelling index,CRP,RF,ESR in treatment group after treatment were（ 28. 9 ± 11. 4） min,（ 9. 3 ± 3. 4） mg · L^-1,（ 6. 7 ± 2. 8） mg · L^-1,（ 20. 3 ± 8. 7） mg·L^-1,（ 104. 5 ± 3. 5） u·mL^-1,（ 22. 1 ± 3. 5） mm·h^-1,respectively. While them in control group were（ 34. 6 ± 13. 6） min,（ 11. 7 ±

关 键 词：白芍总苷 类风湿关节炎 血脂 炎性指标 药物不良反应 

分 类 号：R28[医药卫生—中药学]