中药雾化联合离子导入治疗慢性阻塞性肺疾病急性加重期患者35例临床观察  

Clinical Observation on 35 Patients with Chronic Obstructive Pulmonary Disease at Acute Exacerbation Stage Treated with Herbal Aerosol Inhalation Combined with Iontophoresis

作　　者：刘洋[1] 郑彩霞[1] 师勇[1] 汪严 周永亮[1] 李泽庚 

机构地区：[1]淮北市中医院 [2]安徽中医药大学第一附属医院

出　　处：《中医杂志》2016年第8期669-672,共4页Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药防治重大疑难疾病临床服务能力建设项目(2014mzfyjs006);安徽省省级中医发展专项(2014ZY69)

摘　　要：目的观察中药雾化联合离子导入治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法将70例慢性阻塞性肺疾病急性加重期患者随机分为治疗组和对照组各35例。对照组给予常规西药抗生素及解痉平喘药治疗,治疗组在对照组基础上加用中药雾化及离子导入,每日1次,每次30 min,两组均治疗14天。观察治疗前后患者咳嗽、咯痰、喘息以及湿啰音症状体征积分,检测肺功能及血清C反应蛋白(CRP)与降钙素原(PCT)水平。记录两组患者治疗期间使用抗生素的平均天数,并判定临床疗效。结果治疗组35例中显效30例,好转3例,无效2例,总有效率为94.28%;对照组35例中显效28例,好转3例,无效4例,总有效率为88.57%,两组临床疗效比较差异无统计学意义(P>0.05)。治疗组平均抗生素使用天数明显少于对照组(P<0.05)。两组治疗后喘息、咳嗽、咯痰及湿啰音症状体征积分较治疗前显著降低(P<0.01);治疗后治疗组咳嗽、咯痰积分较对照组改善明显(P<0.05)。治疗后两组组间肺功能比较差异无统计学意义(P>0.05)。两组患者治疗后CRP、PCT较本组治疗前显著降低(P<0.01),且治疗组较对照组降低更明显(P<0.05)。结论中药雾化及离子导入能显著改善患者临床症状,降低炎症指标,减少抗生素的应用。Objective To observe the clinical effect of herbal aerosol inhalation combined with iontophoresis in the treatment of chronic obstructive pulmonary disease（ COPD） at acute exacerbation stage. Methods Seventy COPD patients at acute exacerbation stage were randomized into the treatment group and the control group,with 35 cases in each group. Both groups were given routine western medicine,such as antibiotics,spasmolysis and antiasthmatic medicine. Based on this therapy,the treatment group was added herbal aerosol inhalation and iontophoresis,30 minutes each time,once every day. Both groups were treated for 14 days. Patients＇ symptom and sign scores of cough,expectoration,gasping and moist rales were examined before and after treatment. Pulmonary function,serum C-reactive protein（ CRP） and procalitonin（ PCT） were detected. The average days of using antibiotics during treatment in both groups were recorded. And the clinical effect was evaluated. Results Among 35 cases in the treatment group,30 cases showed marked effect,3 cases improved,and 2 cases without effect. The total effective rate was94. 28%. Among 35 cases in the control group,28 cases showed marked effect,3 cases improved,and 4 cases without effect. The total effective rate was 88. 57%. There was no significant difference in clinical effects between the two groups（ P〉0. 05）. The average days of using antibiotics in the treatment group were much fewer than those in the control group（ P〈0. 05）. After treatment,symptom and sign scores of gasping,cough,expectoration and moist rales decreased in both groups（ P〈0. 01）. The scores of cough and expectoration in the treatment group improved more significantly than those in the control group（ P〈0. 05）. There was no significant difference in pulmonary function between the two groups（ P〉0. 05）. After treatment,CRP and PCT in both groups were much lower than those before treatment（ P〈0. 01）,and those in the treatment group decreased more significantly than those in the c

关 键 词：中药雾化 离子导入 慢性阻塞性肺疾病 C反应蛋白 降钙素原 

分 类 号：R563.9[医药卫生—呼吸系统]