正交试验法优选肝炎康胶囊的醇提制备工艺  

Optimum on the Ethanol-Extraction Procedures of Ganyankang Capsules by Orthogonal Design Test

作　　者：韦亚洁[1] 王娟弟[1,2] 秦龙[1] 李平[1,3] 李玉民[1,3] 张岭漪[1] 代东良 

机构地区：[1]兰州大学第二医院,甘肃兰州730030 [2]兰州大学药学院,甘肃兰州730000 [3]甘肃省消化系肿瘤重点实验室,甘肃兰州730030

出　　处：《中国药业》2016年第6期32-35,共4页China Pharmaceuticals

基　　金：兰州大学第二医院院内中医药科研项目;项目编号:YJzy2013-26

摘　　要：目的优选肝炎康胶囊的醇提制备工艺。方法以浸膏率和大黄素含量作为考察指标,采用正交试验L9（3^4）法,优选肝炎康胶囊的最佳醇提制备工艺。结果影响醇提制备工艺的因素为乙醇浓度（因素A）〉加醇倍量（因素D）〉提取次数（因素C）〉提取时间（因素B）。最佳制备工艺条件为A3B2C2D2,即处方药材加15倍量的80%乙醇,提取2次,每次1.5 h。结论该醇提制备工艺条件合理可行,有效成分提取较完全,可优先用于该制剂的实际配制。Objective To optimize the ethanol-extraction procedures of Ganyangkang Capsules witn orthogonal design test.Methods Using the extract yield and emodin as indexs,the optimum extraction conditions of ganyankang capsules were studied with the orthogo-nal test of L9（3^4）.Results The influencing effects for factor were described as A 〉D 〉C 〉B（A：ethanol concentration,B：extracting frequency,C：extracting times,D：added ethanol volume）.The optimizing preparation conditions were A3B2C2D2,i.e.,added 15 times 80% ethanol,extracting for 2 times and 1.5 h per time.Conclusion The optimum ethanol-extracting procedures are feasible,rational and the extraction rate of active components is perfect,which can be applied to the preparation.

关 键 词：肝炎康胶囊 正交试验 醇提工艺 大黄素 

分 类 号：TQ461[化学工程—制药化工] R284.1[医药卫生—中药学]