复方鱼腥草颗粒中连翘挥发油β-环糊精包合工艺优化研究  

Clathration Craft for β-Cyclodextrin in Essential Oil of Fructus Forsythiae in Fufang Yuxingcao Granules

作　　者：施晓光 

机构地区：[1]广西壮族自治区食品药品检验所,广西南宁530021

出　　处：《中国药业》2016年第6期44-46,共3页China Pharmaceuticals

摘　　要：目的用β-环糊精对复方鱼腥草颗粒中的连翘挥发油进行包合。方法采用正交试验法选择包合工艺的最佳条件,并对包合物的质量进行分析。结果得出的最佳工艺条件为挥发油与β-环糊精的比为10 m L∶80 g,包合时间为4 h,包合温度为60℃,加水量为β-环糊精的8倍。结论该包合工艺简单可行,可有效防止挥发油有效成分的散失。Objective To clathrate the essential oil of Fructus Forsythian in Fufang Yuxingcao Granules with β-cyclodextrin.Methods The optimum condition for clathration craft was chosen by orthogonal tests and the quality of clathrates was analyzed.Results The op-timum craft condition：the proposition of essential oil and β-cyclodextrin was 10 m L ∶80 g;the process was 4 h at 60 °C;8 times of water respect to β-cyclodextrin was added.Conclusion The craft is proved to be simple,operatable and effective to avoid active gra-dients in the essential oil.

关 键 词：复方鱼腥草颗粒 连翘挥发油 Β-环糊精包合物 正交试验 

分 类 号：TQ461[化学工程—制药化工] R284.1[医药卫生—中药学]