罗勒多糖对H22肝癌荷瘤小鼠化疗增效药效学研究  

Basil Polysaccharide Enhances Efficacy of Chemotherapy in H22 He Patoma-bearing Mice

作　　者：于华静 李路[1] 肖丽[2] 张丹[1] 张秋红 朱庆均[1] 

机构地区：[1]山东中医药大学,山东济南250355 [2]山东中医药大学附属医院,山东济南250355 [3]济南市食品药品检验所,山东济南250000

出　　处：《辽宁中医药大学学报》2016年第4期33-35,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：山东省优秀中青年科学家科研奖励基金项目(BS2001YY055;BB2010YY068);山东省高等学校科技计划项目(J14LK09)

摘　　要：目的:研究罗勒多糖对H22荷瘤小鼠化疗增效的影响。方法:通过对H22荷瘤小鼠瘤质量及生存率的检测,观察罗勒多糖与紫杉醇合用对H22荷瘤小鼠的增效作用;通过检测血清谷丙转氨酶、谷草转氨酶及尿素氮,观察罗勒多糖联合化药对H22荷瘤小鼠肝肾的影响。结果:罗勒多糖能在一定程度上增强紫杉醇的抑瘤作用以及提高小鼠生存率,并对肝肾无损伤作用。结论:罗勒多糖对荷瘤小鼠具有一定的化疗增效及提高生存率的作用。Objective：To study the assistant effect of basil polysaccharide in chemotherapy. Methods：By detecting tumor quality and survival rate of H22 hepatoma-bearing mice,observe the assistant effect of basil polysaccharide combining paclitaxel,through the detection of serum alanine aminotransferase,aspartate aminotransferase and urea nitrogen,to observe the effect of basil palysaccharide combined with medicine on H22 hepatoma-bearing mice＇s liver and kidney. Results：To some extent,it can enhance the anti-tumor effect of paclitaxel and improve the survival rate of mice. At the same time,it has no damage to the liver and kidney. Conclusion：Basil polysaccharide enhances efficacy of chemotherapy and improve the survival rate of H22 hepatoma-bearing mice.

关 键 词：罗勒多糖 紫杉醇 H22荷瘤小鼠 增效 生存率 

分 类 号：R284[医药卫生—中药学] R735.7[医药卫生—中医学]