马尔堡病毒疫苗研究进展  

Progress in vaccine development of Marburg virus

作　　者：李拓[1] 刘珠果[1] 戴秋云[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《军事医学》2016年第3期261-264,共4页Military Medical Sciences

摘　　要：马尔堡病毒属丝状病毒科,为单股不分节段负链RNA病毒。1967年发现后已在非洲等地暴发14次,感染588人,死亡482人,总死亡率约为82%。该病毒进入人体后会造成患者多脏器感染,导致严重出血热,最终致感染者死亡。目前临床上缺乏有效的预防性疫苗和感染后治疗药物,但一些疫苗在动物实验上显示有效。该文对马尔堡病毒结构、致病机制及疫苗研究进展进行了简要综述。Marburg virus（ MARV） is a member of the Filoviridae family and belongs to a non-segmented,single-strand and negative-sense RNA virus. Since the first discovery of virus in 1967,infections have broken out 14 times,causing the infection of 588 people and 482 deaths. The mortality is up to 82%. Marburg virus results in multiple organ infections,severe hemorrhagic fever and death. Currently,there are no available licensed vaccines or post-exposure treatment,but the vaccines have proved effective in experimental animals. This review briefly summarizes the structure,infection mechanism and the progress in vaccines of this virus.

关 键 词：马尔堡病毒 感染机制 疫苗 中和抗体 

分 类 号：R392-33[医药卫生—免疫学]