少年接种乙肝疫苗的免疫持久性观察  

Observation on Immune Persistance in Juvenilies Vaccinated with Plasma-derived HB Vaccine

作　　者：章明太[1] 刘克洲[1] 周绍聪[1] 金建华[1] 余乾炎 张秀芝[1] 郑菊梅[2] 孟秀园 王文渊[2] 

机构地区：[1]浙江医科大学传染病研究所 [2]兰州生物制品研究所

出　　处：《中国人兽共患病杂志》1991年第3期8-10,共3页Chinese Journal of Zoonoses

摘　　要：本文以国产血源性乙肝疫苗对98名少年进行了为期4年的观察,结果表明三剂疫苗接种后,T_1抗-HBs阳转率为70.41％,其S/N均值为19.98,于T_3～T_(24)时抗-HBs阳转率达98％,S/N均值分别为65.34、41.75、33.95、23.79。至T_(36)、T_(48)时持续阳性率仍有81.63％、79.59％,S/N均值为12.81、11.18,其中分别有18名、19名抗-HBs转阴。对T_1S/N值>10的47名和<9.9的51名经追踪统计表明,前者的抗-HBs水平、免疫持久性高于后者,而其抗-HBs阴转率高于前者(P<0.05),并对其原因作了分析和讨论。Ninty-eight juveniles vaccinated with native plasma derived HB vaccine have been followed up for four years. The result showed that the positive rate and its mean S/N values of anti-HBs at T1 were 70.41% and 19.98 respectively,at T3,T6,T12,T24,all 98% and 65.34,41.75,33.95,23.79 respectively. The positive rate of remainers occured in 81. 63%, 79. 59% and its S/N mean value were 12. 81,11. 18 respectively at T36 and T48. However out of the 98 mentioned 19 recipents became negative for anti-HBs at T48. After following up 47 recipents with more than 10 of S/N value and 51 recipents with less than 9. 9 of S/N value,we find the levels of anti-HBs in serum of former were higher than that of latter.

关 键 词：乙型肝炎疫苗 免疫应答 

分 类 号：R186[医药卫生—流行病学]