平颏海蛇化学成分的研究Ⅱ  

Study on the Chemical Constituents of Lapemis curtus Ⅱ

作　　者：姚海萍[1,2] 梁振纲 赵李妮 杨先会[1,2] 邓世明[1,2] 

机构地区：[1]海南大学热带生物资源教育部重点实验室,海南海口570228 [2]海南大学海洋学院,海南海口570228

出　　处：《时珍国医国药》2016年第3期599-602,共4页Lishizhen Medicine and Materia Medica Research

基　　金："十二五"国家科技支撑计划课题(No.2013BA01B04);海南省科技兴海专项(No.XH201309)

摘　　要：目的研究平颏海蛇干体的化学成分。方法采用硅胶柱色谱、凝胶柱色谱、重结晶等方法进行分离纯化,根据理化性质和波谱数据鉴定化合物的结构。结果从平颏海蛇干体中分离得到10个化合物,分别鉴定为:棕榈酸(1),油酸甲酯(2),油酸(3),3-methoxycholest-5-ene(4),Stigmasta-5,24(28)-diene,3-methoxy-,(3β,24E)(5),Tetracosanamide,N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3,7-heptadecadien-1-yl](6),5α-Cholestan-3β-ol,5,6β-dibromo-,nonanoate(7),Cholestane-3,5,6-triol,3-nonanoate(8),胆甾-5-烯-3β,7β-二醇(9),胆甾-5-烯-3β,7α-二醇(10)。结论所有化合物均为首次从平颏海蛇中分离得到。Objective To study the chemical constituents of the dry Lapemis curtus. Methods The compounds were separatedby column chromatography and recrystallization, their structures were elucidated based on chemical and spectral analyses.Result Ten compounds were isolated from the dry Lapemis curtus. Their structures were determined as Palmitic acid（ 1）,Octdecenoic acid methyl ester（ 2）,9-octadecenoic acid（ 3）,3-methoxycholest-5-ene（ 4）,Stigmasta-5,24（ 28）-diene,3-methoxy-,（ 3β,24E）（ 5）,Tetracosanamide,N-[（ 1S,2R,3E）-2-hydroxy-1-（ hydroxymethyl）-3,7-heptadecadien-1-yl]（ 6）,5α-Cholestan-3β-ol,5,6β-dibromo-,nonanoate（ 7）,Cholestane-3,5,6-triol,3-nonanoate（ 8）,Cholest-5-ene-3β,7β-diol（ 9）,Cholest-5-ene-3β,7α-diol（ 10）. Conclusion All compounds were isolated from the dry Lapemis curtus for the first time.

关 键 词：平颏海蛇 海洋生物 化学成分 

分 类 号：TQ46[化学工程—制药化工]