A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO_4·5H_2O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid  

作　　者：Hai-Xia Pang Yong-Hai Hui Kui Fan Xue-Jian Xing Yang Wu Jing-Hui Yang Wei Shi Zheng-Feng Xie 

机构地区：[1]Key Laboratory of Oil & Gas Fine Chemicals,Ministry of Education & Xinjiang Uyghur Autonomous Region,College of Chemistry and Chemical Engineering,Xinjiang University [2]Oil & Gas Field Applied Chemistry Key Laboratory of Sichuan Province,School of Chemistry and Chemical Engineering,Southwest Petroleum University

出　　处：《Chinese Chemical Letters》2016年第3期335-339,共5页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21162026,21262034 and 21362036);Doctoral Fund of Xinjiang University(No.BS110111)for financial support,Xinjiang University Analytical&Testing Center for instrumental analyses,and Adamas-beta Chemical Co.,for all chemical reagents

摘　　要：Mesoporous MCM-41 supported Schiff base and Cu SO4· 5H2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines（or aldehydes and amines） to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product in high yields（up to 98% and 99%）.Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.Mesoporous MCM-41 supported Schiff base and Cu SO4· 5H2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines（or aldehydes and amines） to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product in high yields（up to 98% and 99%）.Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.

关 键 词：MCM-41 Schiff base Cyclocondensation Mercaptoacetic acid Catalysis 

分 类 号：O621.251[理学—有机化学]