Chemoselective synthesis of novel aminoindolizines using aminopyridines, acetylenic diesters and α-halo ketones  

作　　者：Sakineh Asghari Mohammad Qandalee Vahideh Behboodi Arastoo Nouri Gorji Ghasem Firouzzade Pash 

机构地区：[1]Department of Organic Chemistry,Faculty of Chemistry,University of Mazandaran [2]Nano and Biotechnology Research Group,University of Mazandaran [3]Department of Biology,Garmsar Branch,Islamic Azad University

出　　处：《Chinese Chemical Letters》2016年第3期361-364,共4页中国化学快报（英文版）

基　　金：supported by the Research Council of the University of Mazandaran,Iran

摘　　要：A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and a-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with a-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.A chemoselective synthesis of novel indolizine derivatives were reported via three-component reactions of aminopyridines, acetylenic diesters and a-halo ketones. In these reactions, the zwitterion generated from aminopyridines and acetylenic diesters reacted with a-halo ketones to produce indolizine skeleton in good to high yields under mild reaction conditions.

关 键 词：Aminopyridines a-Halo ketones Acetylenic diesters Indolizine Chemoselective synthesis 

分 类 号：O621.3[理学—有机化学]