野菊花超临界二氧化碳萃取物的镇痛抗炎作用研究  

Study of Analgesic and Anti-Inflammatory Effect of Chrysanthemum Indicum Supercritical CO_2 Extraction

作　　者：郑继标 吴晓丽[2] 梁丽梅[3] 戴兆燕[1] 孙朝跃 杨红梅[2] 詹雅娴[2] 黎玉翠[2] 

机构地区：[1]湛江中心人民医院药学部,广东湛江524000 [2]广州中医药大学,广东广州511400 [3]广东省人民医院药学部,广东广州510080

出　　处：《今日药学》2016年第3期149-152,共4页Pharmacy Today

基　　金：广东省科技计划项目(2014A020221050)

摘　　要：目的考察野菊花超临界二氧化碳萃取物(SCFE)的镇痛抗炎活性。方法以小鼠扭体法和热板法观察SCFE的镇痛作用;以醋酸致毛细血管通透性增强法和角叉菜胶致小鼠足跖肿胀法观察SCFE的抗炎作用。结果 SCFE中、高剂量组均能显著减少15 min内的扭体次数,提高小鼠的痛阈值;在醋酸致小鼠毛细血管通透性增强模型,能显著的降低毛细血管通透性;在角叉菜胶致小鼠足跖肿胀模型中,SCFE对小鼠足肿胀有显著的抑制作用。结论 SCFE具有显著的镇痛抗炎作用。OBJECTIVE To analyze the activation of analgesic and anti-inflammatory of Chrysanthemum indicum supercritical CO2extraction（ SCFE）. METHODS The analgesic effect of SCFE was observed by writhing test and hot plate test in mice; antiinflammatory effect was investigated by increased capillary permeability induced by acetic acid and carrageenan-induced paw edema in mice. RESULTS In the writhing test and hot plate test,SCFE significantly reduced the writhing times in 15 min,enhanced the pain threshold; in the increased capillary permeability induced by acetic acid model,it reduced capillary permeability; in the carrageenaninduced paw edema model in mice,SCFE had obvious inhibited effect on the paw edema in mice. CONCLUSION SCFE has significant analgesic and anti-inflammatory effects.

关 键 词：野菊花 超临界二氧化碳萃取 镇痛 抗炎 

分 类 号：R284[医药卫生—中药学]