清肝降浊化湿法治疗2型糖尿病伴高脂血症的疗效观察  

Clinical Observation of Clearing Liver Descending Turbidity and Resolving Dampness Method in Treatment of Type 2 Diabetes and Hyperlipidemia

作　　者：赵翠芳[1] 李卉 程璐 关崧[1] 

机构地区：[1]北京中医药大学东方医院,北京100078 [2]北京市房山区中医院,北京100000 [3]北京市密云县中医院,北京100000

出　　处：《世界中医药》2016年第2期253-255,共3页World Chinese Medicine

摘　　要：目的:本实验通过清肝降浊化湿法治疗2型糖尿病合并高脂血症的患者,观察治疗前后的血糖、血脂、糖化血红蛋白等的变化,探讨中医药对糖尿病合并高脂血症的疗效机理。方法:将120例患者随机分为2组。在西药控制血糖的基础上,治疗组60例加服大柴胡汤化裁方(大柴胡汤去姜枣,加生山楂、龙胆草、茵陈、泽泻、丹参等组成)治疗,对照组60例二甲双胍(施贵宝公司生产),每次500 mg,3次/d口服。2组均以12周为1个疗程,连续观察1个疗程。结果:治疗组空腹血糖(FBG)、餐后2 h血糖(P2BG)、糖化血红蛋白(HBA1C)、血清总胆固醇(Tc)、甘低密度脂蛋白-胆固醇(LDL-C)均明显下降,与治疗前比较,差异有统计学意义(P<0.01)。对照组治疗后比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:清肝降浊化湿法对2型糖尿病伴高脂血症有较好的调节作用。Objective： To observe the changes of blood glucose,blood lipid and glycosylated hemoglobin before and after the treatment by clearing liver descending turbidity and resolving dampness method in type 2 diabetes and hyperlipidemia,so as to explore Chinese medicinals mechanism in treating the disease. Methods： Total 120 patients were randomly divided into two groups. On the basis of western medicine to control blood sugar,the treatment group of 60 cases received modified Major Bupleurum Decoction（ Composed of Chinese Thorowax Root,Baical Skullcap Root,wine Rhubarb,Immature Orange Fruit,Gentiana Scabra Bge,raw Hawthorn Fruit,Oriental Waterplantain Rhizome,Virgate Wormwood Herb,Pinellia Tuber,Salvia Root etc.）,500 mg each time,three times a day. The control group of 60 patients received metformin treatment,also 500 mg each time,three times a day.The treatment of both groups had 12 weeks for one course of treatment,and the observation continued one course of treatment. Results： The fasting blood glucose（ FBG）,postprandial 2 hours blood glucose（ P2BG）,glycosylated hemoglobin（ HBA1C）,serum total cholesterol（ Tc）,low density lipoprotein cholesterol（ LDL-C） of treatment group after treatment were significantly decreased,compared with before treatment（ P 〈 0. 01）. And there were significant differences in the control group（ P 〈 0. 05,P 〈0. 01）. Conclusion： Clearing liver descending turbidity and resolving dampness method has clear regulating effect in in type 2 diabetes and hyperlipidemia patients.

关 键 词：2型糖尿病 高脂血症 清肝降浊化湿法 

分 类 号：R587.105[医药卫生—内分泌]