NT-proBNP、cTnI、hs-CRP联合检测在急诊心血管病患者诊治中的应用  

The application of combined detection of the NT-proBNP,cTnI and hs-CRP for the patients with cardiovascular diseases in emergency department

作　　者：蒋剑英[1] 朱笑频[1] 王成刚[1] 方海俊[1] 

机构地区：[1]义乌市中心医院检验科,浙江义乌322000

出　　处：《中国卫生检验杂志》2016年第7期995-997,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的研究联合检测氨基末端B型钠尿肽原(NT-pro BNP)、心肌肌钙蛋白I(c Tn I)和超敏C反应蛋白(hsCRP)在急诊心血管病患者诊治中的作用。方法检测本院急诊室接诊的522例疑似心血管病患者的血浆NT-pro BNP、c Tn I和hs-CRP水平,并跟踪观察心血管病患者在治疗过程中其水平变化。结果 282例心血管病患者血浆NTpro BNP、c Tn I和hs-CRP水平明显高于非心血管病患者,差异具有统计学意义(P<0.01);联合检测NT-pro BNP、c Tn I和hs-CRP用于诊断心力衰竭(HF)患者灵敏度为99%,特异度为78%,优于单项检测。HF患者经治疗后血浆NTpro BNP和c Tn I和hs-CRP水平明显低于治疗前,差异有统计学意义(P<0.01)。对心血管病患者治疗后随访发现,发生心血管事件组NT-pro BNP、c Tn I和hs-CRP水平明显高于未发生心血管事件组,差异有统计学意义(P<0.01)。结论对于急诊室送诊的疑似心血管病患者,及时进行NT-pro BNP、c Tn I和hs-CRP水平的联合检测在诊治中有重要价值。Objective To investigate the diagnosis value of combined detection of NT - proBNP, cTnI and hs - CRP with cardi- ovascular disease in the emergency department. Methods A total of 522 patients with suspected cardiovascular disease were enrolled. The dynamic changes of NT - proBNP, cTnI and hs - CRP levels in patients were followed during the treatment. Re- sults The levels of NT - proBNP, eTnI and hs - CRP in patients with cardiovascular disease was significantly higher in patients with cardiovascular disease than that in non cardiovascular diseases, and the differences were statistically significant （ P 〈 0.01 ）. The sensitivity and specificity of combined detection of NT - proBNP and eTnI, hs - CRP was 99% and 78% respec- tively for the diagnosis of patients with CHF, which was better than that of single detection. After treatment, the levels of plasma NT - proBNP and eTnI, hs - CRP in patients with HF were lower than those before treatment, and the differences were statisti- cally significant（ P 〈 0.01 ）. The follow- up after treatment in patients with cardiovascular disease indicated that the levels of patients with cardiovascular events were significantly higher than those without cardiovascular events, and the differences were statistically significant（ P 〈 0.01 ）. Conclusion Combined detection of NT - proBNP, cTnI, and hs - CRP detection is valua- ble for the diagnosis of patients with cardiovascular diseases in emergency department.

关 键 词：氨基末端B型钠尿肽原 心肌肌钙蛋白I 超敏C反应蛋白 心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]