丙烯腈从业人员及宁波市居民尿硫氰酸盐水平调查  

Surveillance on urinary thiocyanate levels among acrylonitrile practitioners and residents in Ningbo

作　　者：龚敏莉 李波 郝玲妹 

机构地区：[1]宁波市第七医院检验科,浙江宁波315202 [2]宁波市第七医院呼吸科,浙江宁波315202

出　　处：《中国卫生检验杂志》2016年第7期1038-1039,1042,共3页Chinese Journal of Health Laboratory Technology

基　　金：宁波市医学科技计划项目(2011B27);宁波市镇海社发项目(2012S013)

摘　　要：目的建立宁波市居民尿硫氰酸盐(USCN)参考值范围,为丙烯腈(ACN)从业人员健康监护评价提供科学依据。方法收集在宁波市居住3年以上的ACN从业人员(A组)和化工区辐射5公里之内居民(B组)及远离化工区10公里之外居民(C组)的晨尿,用吡啶-巴比妥酸自动测定法检测USCN,同时测定尿肌酐含量。结果男、女2组USCN水平比较,校正前及校正后差异均有统计学意义(t值分别为3.06、3.23,P<0.05)。校正前及校正后A组、B组、C组人群之间USCN水平差异均无统计学意义(F值分别为2.817、1.251,P>0.05),同组人群校正前及校正后USCN水平差异均有统计学意义(P<0.05)。吸烟组与非吸烟组校正后USCN水平随着吸烟量的增加呈上升趋势,差异有统计学意义(F=95.76,P<0.05)。结论宁波市健康人群校正后USCN正常参考值:吸烟人群为2.07 mg/g Cr,非吸烟人群为1.32 mg/g Cr。Objective To establish the reference values range for urinary thiocyanate（ USCN） in residents of Ningbo,so as to provide scientific basis for the health monitoring and evaluation of acrylonitrile（ ACN） practitioners. Methods The first morning urine samples from ACN practitioners（ A group） living in Ningbo for 3 years,the residents living within 5 km of chemical area（ B group） and residents living 10 km away from the chemical area（ C group） were collected for the detection of USCN and urine creatinine levels in the urine with pyridine- barbituric acid automatic measurement detector. Results The differences of USCN levels in males and females,before creatinine correction and after creatinine correction were statistically significant（ t =3. 06,3. 23,P〈0. 05）. The differences of USCN levels among the 3 groups between before creatinine correction and after creatinine correction were not statistically significant（ F = 2. 817,1. 251,P〈0. 05）,the difference in the same group between before creatinine correction and after creatinine correction was statistically significant（ P〈0. 05）. USCN levels of smoking group and non- smoking group after creatinine correction increased with the severity of smoking,and the difference was statistically significant（ F = 95. 76,P〈0. 05）. Conclusion The adjusted USCN normal reference value for smokers is 2. 07 mg / g Cr for smokers and 1. 32 mg / g Cr for non- smokers.

关 键 词：尿硫氰酸盐 正常参考值 丙烯腈 健康监护 

分 类 号：R135.1[医药卫生—劳动卫生]