索利那新在膀胱结石腔内碎石治疗中的应用  

Application of solifenacin in intracavity lithotripsy for cystolith

作　　者：洪辉斌 王乐浩 

机构地区：[1]广东省汕头市第二人民医院泌尿外科,515011

出　　处：《中国实用医药》2016年第7期1-3,共3页China Practical Medicine

基　　金：汕头市科技计划项目[项目编号:汕府科(2013)88]

摘　　要：目的观察评测膀胱结石合并膀胱过度活动症(OAB)患者行腔内碎石术前、术后早期使用索利那新的临床疗效和不良反应。方法 60例采用单纯经尿道膀胱结石腔内碎石取石术的膀胱结石合并OAB患者,随机分为实验组与对照组,每组30例。实验组于术晨开始口服琥珀酸索利那新片5 mg/次,1次/d,口服至拔除导尿管后3 d;对照组予以常规治疗。观察比较两组患者术后膀胱痉挛、尿急、尿频、急迫性尿失禁情况。结果两组患者手术均一次成功,无结石残留。实验组术后膀胱痉挛次数、持续时间明显少于对照组,差异有统计学意义(P<0.05);夜尿次数、24 h平均尿量多于对照组,差异有统计学意义(P<0.05)。术后两组24 h平均尿急次数、急迫性尿失禁次数及排尿次数明显少于术前,且实验组优于对照组,差异具有统计学意义(P<0.05)。结论膀胱结石合并OAB患者行腔内碎石术前、术后早期使用索利那新,对缓解术后膀胱痉挛、尿急、尿频、急迫性尿失禁等症状有良好的效果,值得临床推广应用。Objective To observe and evaluate clinical effect and adverse reactions by early preoperative and postoperative application of solifenacin in intracavity lithotripsy for cystolith complicated with overactive bladder（OAB）. Methods A total of 60 patients of cystolith complicated with OAB receiving simple transurethral intracavity lithotripsy were randomly divided into experimental group and control group, with 30 cases in each group. The experimental group received succinic acid solifenacin tablet by 5 mg/time once a day through oral administration till 3 d after catheter extubation. The control group received conventional treatment. Observations were made on postoperative cystospasm, urgent urination, frequent micturition, and urge incontinence. Results Both groups received successful operation, without residual stones. The experimental group had obviously less postoperative cystospasm times and last time than the control group, and their difference had statistical significance（P〈0.05）. The experimental group had more nocturnal enuresis times and 24 h average urine volume than the control group, and the difference had statistical significance（P〈0.05）. Both groups had obviously less postoperative 24 h average urgent urination times, urge incontinence times and urination times than the control group, and those in the experimental group were better than the control group, the difference had statistical significance（P〈0.05）. Conclusion Early preoperative and postoperative application of solifenacin in intracavity lithotripsy for cystolith complicated with OAB provides good effect in relieving postoperative postoperative cystospasm, urgent urination, frequent micturition, and urge incontinence. This method is worth clinical promotion and application.

关 键 词：索利那新 膀胱结石 膀胱过度活动症 

分 类 号：R699.5[医药卫生—泌尿科学]