慢性心力衰竭患者CA125水平与炎性因子表达相关性研究  

The relationship between CA125 levels and inflammatory cytokines in patients with chronic heart failure

作　　者：钟鸣[1] 傅慎文[1] 刘爱霞[1] 朱以军[1] 郑新玲[1] 杨伊萍[1] 

机构地区：[1]浙江省金华市中心医院心血管内一科,321000

出　　处：《心电与循环》2016年第2期81-83,共3页Journal of Electrocardiology and Circulation

基　　金：浙江省医学会临床科研基金项目(2011ZYC-A98)

摘　　要：目的探讨慢性心力衰竭患者血清CA125与IL6、TNF-α间的关系。方法入选心力衰竭患者38例(NYHAⅠ/Ⅱ级组18例,NYHAⅢ/ⅣV级组20例)和健康体检者(对照组)15例。检测患者入院后次日清晨CA125、IL6、TNF-α和BNP水平,并分析CA125与上述其他指标的关系。结果 NYHAⅠ/Ⅱ级、NYHAⅢ/ⅣV级组患者血清CA125、IL6、TNF-o及BNP水平均高于对照组,差异有统计学意义(H=22.6、32.4、17.7、35.6,均P<0.05或0.01)。NYHAⅢ/Ⅳ级组患者血清CA125、IL6、TNF-α及BNP水平明显高于NYHAⅠ/Ⅱ级组患者(均P<0.01)。血清CA125与IL6、TNF-α、BNP均呈线性正相关(r=0.718、0.559、0.786,均P<0.01)。结论慢性心力衰竭患者血清CA125水平升高,与IL6和TNF-α增高相关。Objective To assess the relationship between serum carbohydrate antigen 125（CA125） and inflammatory cytokines in patients with chronic heart failure （HF）. Methods A total of 38 HF patients and 15 healthy individuals were enrolled in this study. HF patients were divided into mild HF （NYHA classI/Ⅱ, n=18） and severe HF （NYHA classⅢ/Ⅳ, n=20） group. Serum CA125, IL6、TNF- αand plasma BNP levels were measured in the second morning after hospitalization. Results Serum CA125, IL6 ,TNF- αand BNP were significantly higher in HF patients than in healthy individuals（al P〈0.01）, significantly higher in severe HF patients than in mild HF patients（al P〈0.01）. Serum CA125 levels was positively related to IL6（r=0.718, P〈0.01）, TNF- α（r=0.559, P〈0.01）, and BNP levels（r=0.786, P〈0.01）. Conclusion Serum CA125 is elevated in patients with HF. This is associated with increased IL6 and TNF- α.

关 键 词：慢性心力衰竭 CA125 炎性因子 B型脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]